Atopic dermatitis: pathophysiology
The pathophysiology of atopic dermatitis is complex and multifactorial, involving elements of
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated …
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated …
Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them?
Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …
Genetic and epigenetic studies of atopic dermatitis
L Bin, DYM Leung - Allergy, Asthma & Clinical Immunology, 2016 - Springer
Background Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex
interaction of genetic, immune and environmental factors. There have many recent …
interaction of genetic, immune and environmental factors. There have many recent …
The role of tight junctions in skin barrier function and dermal absorption
K Bäsler, S Bergmann, M Heisig, A Naegel… - Journal of Controlled …, 2016 - Elsevier
The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …
3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function
H Niehues, JA Bouwstra, A El Ghalbzouri… - Experimental …, 2018 - Wiley Online Library
The skin barrier is an important shield regulating the outside‐in as well as inside‐out
penetration of water, nutrients, ions and environmental stimuli. We can distinguish four …
penetration of water, nutrients, ions and environmental stimuli. We can distinguish four …
Claudin-1, a double-edged sword in cancer
Claudins, a group of membrane proteins involved in the formation of tight junctions, are
mainly found in endothelial or epithelial cells. These proteins have attracted much attention …
mainly found in endothelial or epithelial cells. These proteins have attracted much attention …
Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
S Bergmann, B von Buenau, S Vidal-y-Sy, M Haftek… - Scientific reports, 2020 - nature.com
The transmembrane protein claudin-1 is a major component of epidermal tight junctions
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …
Epidermal tight junctions in health and disease
JM Brandner, M Zorn-Kruppa, T Yoshida, I Moll… - Tissue …, 2015 - Taylor & Francis
The skin, the largest organ of the body, is an essential barrier that under homeostatic
conditions efficiently protects and/or minimizes damage from both environmental (eg …
conditions efficiently protects and/or minimizes damage from both environmental (eg …
Role of antimicrobial peptides in skin barrier repair in individuals with atopic dermatitis
HLT Nguyen, JV Trujillo-Paez, Y Umehara… - International Journal of …, 2020 - mdpi.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that exhibits a
complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are …
complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are …
Skin barrier defects in atopic dermatitis: From old idea to new opportunity
T Yoshida, LA Beck, A De Benedetto - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis (AD) is the most common chronic skin inflammatory disease, with a
profound impact on patients' quality of life. AD varies considerably in clinical course, age of …
profound impact on patients' quality of life. AD varies considerably in clinical course, age of …