The pathophysiology of atopic dermatitis is complex and multifactorial, involving elements of
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated …

Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

Background Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex
interaction of genetic, immune and environmental factors. There have many recent …

The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

The skin barrier is an important shield regulating the outside‐in as well as inside‐out
penetration of water, nutrients, ions and environmental stimuli. We can distinguish four …

Claudins, a group of membrane proteins involved in the formation of tight junctions, are
mainly found in endothelial or epithelial cells. These proteins have attracted much attention …

The transmembrane protein claudin-1 is a major component of epidermal tight junctions
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …

The skin, the largest organ of the body, is an essential barrier that under homeostatic
conditions efficiently protects and/or minimizes damage from both environmental (eg …

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that exhibits a
complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are …

abstract Atopic dermatitis (AD) is the most common chronic skin inflammatory disease, with a
profound impact on patients' quality of life. AD varies considerably in clinical course, age of …