A variety of stimuli utilize an increase of cytosolic free Ca2+ concentration as a second
messenger to transmit signals, through Ca2+ release from the endoplasmic reticulum or …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade
that plays a pivotal role in energy homeostasis. Activation of AMPK requires phosphorylation …

This article updates the Calcium Hypothesis of Alzheimer's disease and brain aging on the
basis of emerging evidence since 1994 (The present article, with the subtitle “New evidence …

The Ca2+ ATP ases of the plasma membrane (PMCA pumps) export Ca2+ from all
eukaryotic cells. In mammals they are the products of four separate genes. PMCA types 1 …

Ca2+ is a universal second messenger controlling a wide variety of cellular reactions and
adaptive responses. The initial appreciation of Ca2+ as a universal signalling molecule was …

Physiological stimuli causing an increase of cytosolic free Ca 2+[Ca 2+] _c or the release of
Ca 2+ from the endoplasmic reticulum invariably induce mitochondrial Ca 2+ uptake, with a …

Summary The plasma membrane Na+/Ca 2+ exchanger (NCX) is almost certainly the major
Ca 2+ extrusion mechanism in cardiac myocytes. Binding of Na+ and Ca 2+ ions to its large …

Instant Notes in Biochemistry, 2/e provides an easy access to the fundamentals in this field.
The book is a major update on the very successful first edition with expanded coverage of …

The mitochondrial permeability transition (PT) is a well-recognized phenomenon that allows
mitochondria to undergo a sudden increase of permeability to solutes with molecular …