Breast cancer is a common malignancy among women worldwide. Regardless of the
economic status of a country, breast cancer poses a burden in prevention, diagnosis and …

Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor
prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the …

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

The determination of the alternative splicing isoforms expressed in cancer is fundamental for
the development of tumor-specific molecular targets for prognosis and therapy, but it is …

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

Pancreatic cancer remains difficult to treat and has a high mortality rate. It is difficult to
diagnose early, mainly due to the lack of screening imaging modalities and specific …

AMP kinase (AMPK) is an evolutionarily conserved enzyme required for adaptive responses
to various physiological and pathological conditions. AMPK executes numerous cellular …

The tumor microenvironment is fundamental to cancer progression, and the influence of its
mechanical properties is increasingly being appreciated. Tamoxifen has been used for …

Alternative splicing emerges as a potent and pervasive mechanism of gene expression
regulation that expands the coding capacity of the genome and forms an intermediate layer …