Reading, writing and erasing mRNA methylation

S Zaccara, RJ Ries, SR Jaffrey - Nature reviews Molecular cell biology, 2019 - nature.com
RNA methylation to form N 6-methyladenosine (m6A) in mRNA accounts for the most
abundant mRNA internal modification and has emerged as a widespread regulatory …

Insights into N6-methyladenosine and programmed cell death in cancer

L Liu, H Li, D Hu, Y Wang, W Shao, J Zhong, S Yang… - Molecular cancer, 2022 - Springer
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA
modification in eukaryotes, has gained increasing attention and become a hot research topic …

METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy

Y Sun, W Shen, S Hu, Q Lyu, Q Wang, T Wei… - Journal of Experimental …, 2023 - Springer
Background Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer.
Although most patients are initially sensitive to first-line combination chemotherapy with …

Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases

P Wang, KA Doxtader, Y Nam - Molecular cell, 2016 - cell.com
Summary N 6-methyladenosine (m 6 A) is a prevalent, reversible chemical modification of
functional RNAs and is important for central events in biology. The core m 6 A writers are …

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

X Wang, J Feng, Y Xue, Z Guan, D Zhang, Z Liu… - Nature, 2016 - nature.com
Chemical modifications of RNA have essential roles in a vast range of cellular processes,,. N
6-methyladenosine (m6A) is an abundant internal modification in messenger RNA and long …

Means, mechanisms and consequences of adenine methylation in DNA

K Boulias, EL Greer - Nature Reviews Genetics, 2022 - nature.com
Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

S Akichika, S Hirano, Y Shichino, T Suzuki… - Science, 2019 - science.org
INTRODUCTION N 6-methyladenosine (m6A), an abundant modification in eukaryotic
mRNAs and long-noncoding RNAs, has been recognized as a major epitranscriptome mark …

Structural insights into the molecular mechanism of the m6A writer complex

P Śledź, M Jinek - elife, 2016 - elifesciences.org
Methylation of adenosines at the N6 position (m6A) is a dynamic and abundant
epitranscriptomic mark that regulates critical aspects of eukaryotic RNA metabolism in …

Dynamics of DNA methylation and its functions in plant growth and development

S Kumar, T Mohapatra - Frontiers in Plant Science, 2021 - frontiersin.org
Epigenetic modifications in DNA bases and histone proteins play important roles in the
regulation of gene expression and genome stability. Chemical modification of DNA base …

Epigenetics of modified DNA bases: 5-methylcytosine and beyond

S Kumar, V Chinnusamy, T Mohapatra - Frontiers in genetics, 2018 - frontiersin.org
Modification of DNA bases plays vital roles in the epigenetic control of gene expression in
both animals and plants. Though much attention is given to the conventional epigenetic …