Frostbite, a debilitating condition, significantly affects the well-being of military veterans and
high-altitude residents, causing severe clinical complications such as chronic pain that …

This study aimed to assess the possible systemic antinociceptive activity of mangiferin and
to clarify the underlying mechanism, using the acute models of chemical (acetic acid …

Context: Peripheral axon injury and degeneration are often mediated by oxidative stress and
inflammation. The hydroalcoholic extract of the red propolis (HERP) has attracted great …

Four original cocrystal structures incorporating a zwitterionic amino acid, prolinium, and a
therapeutical agent from profen pharmaceutical family, naproxen, are highlighted and …

This study used various experimental pain methods to investigate the effects of subacute
mianserin administration on diabetes-induced neuropathic pain in rats. The effect of …

In this study, we investigated the effects of subacute agomelatine (40 and 80 mg/kg)
administration on chronic hyperglycemia, metabolic parameters, and pain perception in …

This study assessed the effect of the combination of anethole and ibuprofen in comparison
with monotherapy by either drug alone, using two in vivo inflammatory models, namely the …

Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not
amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non …

Diabetic neuropathy (DN) is a common complication of diabetes mellitus that is hardly
reversible at the late stages. Since treatment of neuropathic pain is predominantly …

The effects of maslinic acid (1), a pentacyclic triterpenoid obtained from Olea europaea,
were studied in several tests for nociception in mice. Systemic administration of 1 reduced …