Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Cardiolipin (CL) is a structurally unique dimeric phospholipid localized in the inner
mitochondrial membrane where it is required for optimal mitochondrial function. In addition …

Accumulation of oxidative damage to mitochondria, protein, and nucleic acid in the brain
may lead to neuronal and cognitive dysfunction. The effects on cognitive function, brain …

Cardiolipin is a unique phospholipid which is almost exclusively located at the level of the
inner mitochondrial membrane where it is biosynthesized. This phospholipid is known to be …

Mitochondria are a cell's single greatest source of reactive oxygen species. Reactive oxygen
species are important for many life sustaining processes of cells and tissues, but they can …

To provide a global analysis of gene expression in the aging heart, we monitored the
expression of 9,977 genes simultaneously in 5-and 30-month-old male B6C3F1 mice by …

Mitochondrial function and ambulatory activity were monitored after feeding old rats acetyl-l-
carnitine (ALCAR). Young (3–5 mo) and old (22–28 mo) rats were given a 1.5%(wt/vol) …

It is becoming increasingly evident that the mitochondrial genome may play a key role in
neurodegenerative diseases. Mitochondrial dysfunction is characteristic of several …

Ischemia-reperfusion injury to cardiac myocytes involves membrane damage mediated by
oxygen free radicals. Lipid peroxidation is considered a major mechanism of oxygen free …

ABSTRACT A diet supplemented with (R)‐lipoic acid, a mitochondrial coenzyme, was fed to
old rats to determine its efficacy in reversing the decline in metabolism seen with age. Young …