The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological
processes through various mechanisms that are not fully understood. Proposed …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

As an efficient class of hydrogel-based therapeutic drug delivery systems, deoxyribonucleic
acid (DNA) hydrogels (particularly DNA nanogels) have attracted massive attention in the …

Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding
transcripts exhibit nuclear localization and several have been shown to play a role in the …

Triple-negative breast cancer (TNBC) exhibits poor prognosis, with high metastasis and low
survival. Long non-coding RNAs (lncRNAs) play critical roles in tumor progression. Here, we …

There is a growing perception that long non-coding RNAs (lncRNAs) modulate cellular
function. In this study, we analyzed the role of the lncRNA HOTAIR in mesenchymal stem …

Clinical genomics promises unprecedented precision in understanding the genetic basis of
disease. Understanding the impact of variation across the genome is required to realize this …

The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes
place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal …

The recognition of RNA functions beyond canonical protein synthesis has challenged the
central dogma of molecular biology. Indeed, RNA is now known to directly regulate many …