Epilepsy is a chronic neurological disorder that presents as recurrent, unprovoked seizures.
Pharmacotherapy is the main treatment for epilepsy, but at least 30% of patients with …

Background Typical patients with KCNQ2 (OMIM# 602235) epileptic encephalopathy
present early neonatal‐onset intractable seizures with a burst suppression EEG pattern and …

Purpose We aimed to study the efficacy of adrenocorticotropic hormone (ACTH) treatment
on infantile spasms with different aetiologies. In particular, we were interested in patients …

Background Infantile epileptic spasms syndrome (IESS) with Down syndrome has good
treatment response and good seizure outcomes with high-dose adrenocorticotrophic …

Objective To determine whether high-dose, oral pyridoxine in combination with standard
adrenocorticotropic hormone (ACTH) therapy has superior effectiveness than ACTH therapy …

Background Infantile epileptic spasms syndrome (IESS) with Down syndrome has good
treatment response and good seizure outcomes with high-dose adrenocorticotrophic …

婴儿癫痫性痉挛综合征(IESS) 是最近几年提出的一个新概念, 是一种独特的,
具有年龄特异性的难治性癫痫综合征. 近年来, 随着分子生物学, 神经免疫学的发展以及抗癫痫 …

Purpose Infantile epileptic spasms syndrome (IESS) with periventricular leukomalacia (PVL)
has a poor neurological prognosis. Adrenocorticotropic hormone (ACTH) and vigabatrin …

Objective To evaluate whether serum matrix metallopeptidase-9 (MMP-9) and tissue
inhibitor of metalloproteinase-1 (TIMP-1) levels predict response to adrenocorticotropic …

Background Perampanel is an antiepileptic drug. Some studies have documented the
efficacy of perampanel in epileptic spasms. We aimed to evaluate the efficacy and safety of …