Radiotheranostics in oncology: making precision medicine possible

EO Aboagye, TD Barwick… - CA: a cancer journal for …, 2023 - Wiley Online Library
A quintessential setting for precision medicine, theranostics refers to a rapidly evolving field
of medicine in which disease is diagnosed followed by treatment of disease‐positive …

Cold Kit Labeling: The Future of 68Ga Radiopharmaceuticals?

N Lepareur - Frontiers in Medicine, 2022 - frontiersin.org
Over the last couple of decades, gallium-68 (68Ga) has gained a formidable interest for PET
molecular imaging of various conditions, from cancer to infection, through cardiac …

Imaging of CXC motif chemokine receptor 4 expression in 690 patients with solid or hematologic neoplasms using 68Ga-pentixafor PET

AK Buck, A Haug, N Dreher, A Lambertini… - Journal of Nuclear …, 2022 - Soc Nuclear Med
In recent years, molecular imaging addressing the CXC motif chemokine receptor 4
(CXCR4) has increasingly been used in various clinical settings. Here, we aimed to assess …

CXCR4-targeted theranostics in oncology

AK Buck, SE Serfling, T Lindner, H Hänscheid… - European Journal of …, 2022 - Springer
A growing body of literature reports on the upregulation of CXC motif chemokine receptor 4
(CXCR4) in a variety of cancer entities, rendering this receptor as suitable target for …

Clinical advances and perspectives in targeted radionuclide therapy

N Lepareur, B Ramée, M Mougin-Degraef… - Pharmaceutics, 2023 - mdpi.com
Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …

In vivo targeting of CXCR4—new horizons

M Schottelius, K Herrmann, C Lapa - Cancers, 2021 - mdpi.com
Simple Summary Beyond its pre-eminent role in the context of tumor cell growth as well as
metastasis, the CXC motif chemokine receptor 4 (CXCR4) is a key player in the …

[HTML][HTML] A new class of PentixaFor-and PentixaTher-based theranostic agents with enhanced CXCR4-targeting efficiency

T Osl, A Schmidt, M Schwaiger, M Schottelius… - Theranostics, 2020 - ncbi.nlm.nih.gov
Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as
CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical …

Advances in PET imaging of the CXCR4 receptor:[68Ga] Ga-PentixaFor

L Lindenberg, M Ahlman, F Lin, E Mena… - Seminars in Nuclear …, 2024 - Elsevier
Highlights•[68 Ga] Ga-PentixaFor is a new molecular imaging agent targeting the CXC motif
chemokine ligand 12 (CXCL12)-Chemokine receptor-4 (CXCR4) chemokine axis.•CXCR4 is …

Radiolabelled peptides for positron emission tomography and endoradiotherapy in oncology

C Rangger, R Haubner - Pharmaceuticals, 2020 - mdpi.com
This review deals with the development of peptide-based radiopharmaceuticals for the use
with positron emission tomography and peptide receptor radiotherapy. It discusses the pros …

CXCR4-directed PET/CT in patients with newly diagnosed neuroendocrine carcinomas

A Weich, RA Werner, AK Buck, PE Hartrampf… - Diagnostics, 2021 - mdpi.com
We aimed to elucidate the diagnostic potential of the CXC motif chemokine receptor 4
(CXCR4)-directed positron emission tomography (PET) tracer 68Ga-Pentixafor in patients …