Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …

The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

Fibrosis is a hallmark of aging tissues which often leads to altered architecture and function.
The ovary is the first organ to show overt signs of aging, including increased fibrosis in the …

The ovary is perhaps the most dynamic organ in the human body, only rivaled by the uterus.
The molecular mechanisms that regulate follicular growth and regression, ensuring ovarian …

Historically, research in ovarian biology has focused on folliculogenesis, but recently the
ovarian stroma has become an exciting new frontier for research, holding critical keys to …

Zinc is a critical component in a number of conserved processes that regulate female germ
cell growth, fertility, and pregnancy. During follicle development, a sufficient intracellular …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Significance: The precipitous age-related decline in female fertility is intimately associated
with a reduction in both the quantity and quality of the germline (oocytes). Although complex …