Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of
high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5 …

The majority of coronary atherothrombotic events presenting as myocardial infarction (MI)
occur as a result of plaque rupture or erosion. Understanding the evolution from a stable …

BACKGROUND: 5-Aminolevulinic acid is used for fluorescence-guided resections. During
resection, different macroscopic fluorescence qualities (“strong,”“weak”) can be …

Object Accurate discrimination between tumor and normal tissue is crucial for optimal tumor
resection. Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously …

OBJECT Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin
IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide …

Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering,
biophysics, computer science, medicine, biology, and chemistry, helping us understand light …

Biomarkers are indicators of biological processes and hold promise for the diagnosis and
treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked …

Extent of resection is a major goal and prognostic factor in the treatment of gliomas. In this
study we evaluate whether quantitative ex vivo tissue measurements of δ-aminolevulinic …

Intraoperative visual fluorescence imaging (vFI) has emerged as a promising aid to surgical
guidance, but does not fully exploit the potential of the fluorescent agents that are currently …

Simple Summary Gliomas are aggressive central nervous system tumours. The emergence
and recent widespread adoption of 5-aminolevulinic acid and fluorescence guided surgery …