[HTML][HTML] Toward uncharted territory of cellular heterogeneity: advances and applications of single-cell RNA-seq
Among single-cell analysis technologies, single-cell RNA-seq (scRNA-seq) has been one of
the front runners in technical inventions. Since its induction, scRNA-seq has been well …
the front runners in technical inventions. Since its induction, scRNA-seq has been well …
Isocell: An approach to enhance single cell clustering by integrating isoform-level expression through orthogonal projection
Single cell RNA sequencing (scRNA-seq) provides a powerful approach for profiling
transcriptomes at single cell resolution. An essential application of scRNA-seq is the …
transcriptomes at single cell resolution. An essential application of scRNA-seq is the …
[HTML][HTML] A flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle
K Davey, D Wong, F Konopacki, E Kwa, T Ly… - Scientific Reports, 2021 - nature.com
Single cell transcriptome profiling has emerged as a breakthrough technology for the high-
resolution understanding of complex cellular systems. Here we report a flexible, cost …
resolution understanding of complex cellular systems. Here we report a flexible, cost …
[HTML][HTML] Exploring the complexity of cortical development using single-cell transcriptomics
The developing neocortex in the mammalian brain is composed of multiple cell types
including apical progenitors (AP), basal progenitors (BP), and neurons that populate three …
including apical progenitors (AP), basal progenitors (BP), and neurons that populate three …
Single‐cell RNA‐seq: Introduction to bioinformatics analysis
F Ji, RI Sadreyev - Current protocols in molecular biology, 2019 - Wiley Online Library
Quantitative analysis of single‐cell RNA sequencing (RNA‐seq) is crucial for discovering the
heterogeneity of cell populations and understanding the molecular mechanisms in different …
heterogeneity of cell populations and understanding the molecular mechanisms in different …
Exploiting single-cell RNA sequencing data to link alternative splicing and cancer heterogeneity: A computational approach
Cell heterogeneity studies using single-cell sequencing are gaining great significance in the
era of personalized medicine. In particular, characterization of tumor heterogeneity is an …
era of personalized medicine. In particular, characterization of tumor heterogeneity is an …
Single-cell analysis of the transcriptome and epigenome
Epigenome regulation has emerged as an important mechanism for the maintenance of
organ function in health and disease. Dissecting epigenomic alterations and resultant gene …
organ function in health and disease. Dissecting epigenomic alterations and resultant gene …
Uncertainty versus variability: Bayesian methods for analysis of scRNA-seq data
Y Huang, G Sanguinetti - Current Opinion in Systems Biology, 2021 - Elsevier
Single-cell 'omics technologies have the potential to revolutionize our understanding of
stochasticity and heterogeneity in biology, yet such measurements are inevitably affected by …
stochasticity and heterogeneity in biology, yet such measurements are inevitably affected by …
[HTML][HTML] A scalable strand-specific protocol enabling full-length total RNA sequencing from single cells
S Haile, RD Corbett, VG LeBlanc, L Wei… - Frontiers in …, 2021 - frontiersin.org
RNA sequencing (RNAseq) has been widely used to generate bulk gene expression
measurements collected from pools of cells. Only relatively recently have single-cell …
measurements collected from pools of cells. Only relatively recently have single-cell …
An NMF-based approach to discover overlooked differentially expressed gene regions from single-cell RNA-seq data
H Matsumoto, T Hayashi, H Ozaki… - NAR Genomics and …, 2020 - academic.oup.com
Single-cell RNA sequencing has enabled researchers to quantify the transcriptomes of
individual cells, infer cell types and investigate differential expression among cell types …
individual cells, infer cell types and investigate differential expression among cell types …