RNA sequencing (RNAseq) has been widely used to generate bulk gene expression
measurements collected from pools of cells. Only relatively recently have single-cell …

Single-cell RNA sequencing has enabled researchers to quantify the transcriptomes of
individual cells, infer cell types and investigate differential expression among cell types …

Following the central dogma of molecular biology, gene expression variability can aid in
predicting and explaining the wide variety of protein products, functions, and, ultimately …

Background: The advent of single-cell RNA sequencing (scRNA-seq) technology has
offered unprecedented opportunities to unravel cellular heterogeneity and functions. Yet …

Apart from diseases caused by the defect of a single gene, most diseases are highly
complex and are usually caused by a combination of biological and environmental factors …

Alternative polyadenylation (APA) is a key layer of gene expression regulation, and APA
choice is finely modulated in cells. Advances in single-cell RNA-seq (scRNA-seq) have …

Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by mutations
in the DMD gene encoding for the structural muscle protein dystrophin. Absence of …

Microscopy and omics are complementary approaches to probe the molecular state of cells
in health and disease, combining granularity with scalability. While important advances have …

Computational machines have become an inseparable part of human lives during the last
three decades. One of the crucial enabling technologies of this technological boom is …

Bayesian approach is a powerful tool to solve challenging questions in life sciences. One
such area of life sciences in which Bayesian approach has seen an increased utility in the …