Highlights•RNA-seq is emerging as a powerful technology to study alternative splicing.•RNA
mis-splicing can cause cancers and a variety of other human diseases.•To target alternative …

The outcome of fungal infections depends on interactions with innate immune cells. Within a
population of macrophages encountering Candida albicans, there are distinct host …

Adrenal glands are the major organs releasing catecholamines and regulating our stress
response. The mechanisms balancing generation of adrenergic chromaffin cells and …

The extent splicing is regulated at single-cell resolution has remained controversial due to
both available data and methods to interpret it. We apply the SpliZ, a new statistical …

Five-prime single-cell RNA-seq (scRNA-seq) has been widely employed to profile cellular
transcriptomes, however, its power of analysing transcription start sites (TSS) has not been …

RNA splicing is an important driver of heterogeneity in single cells through the expression of
alternative transcripts and as a determinant of transcriptional kinetics. However, the intrinsic …

Following the central dogma of molecular biology, gene expression heterogeneity can aid in
predicting and explaining the wide variety of protein products, functions and, ultimately …

Alternative splicing is an important source of heterogeneity underlying gene expression
between individual cells but remains an understudied area due to the paucity of …

Alteration of host cell splicing is a common feature of many viral infections which is
underappreciated because of the complexity and technical difficulty of studying alternative …

Single-cell RNA sequencing provides powerful insight into the factors that determine each
cell's unique identity. Previous studies led to the surprising observation that alternative …