Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …
environment or partition cells into distinct compartments. These membranes are lipid …
SARS-CoV-2 cell entry beyond the ACE2 receptor
SD Alipoor, M Mirsaeidi - Molecular biology reports, 2022 - Springer
Background Angiotensin-converting enzyme 2 (ACE2) is known as the major viral entry site
for SARS-CoV-2. However, viral tissue tropism and high rate of infectivity do not directly …
for SARS-CoV-2. However, viral tissue tropism and high rate of infectivity do not directly …
The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase
INTRODUCTION Eukaryotic cells contain membrane-bound organelles with distinct
identities and functionalities that depend on protein composition. Correct localization of …
identities and functionalities that depend on protein composition. Correct localization of …
Structure and activation mechanism of the hexameric plasma membrane H+-ATPase
The S. cerevisiae plasma membrane H+-ATPase, Pma1, is a P3A-type ATPase and the
primary protein component of the membrane compartment of Pma1 (MCP). Like other …
primary protein component of the membrane compartment of Pma1 (MCP). Like other …
Structure of the Wilson disease copper transporter ATP7B
ATP7A and ATP7B, two homologous copper-transporting P1B-type ATPases, play crucial
roles in cellular copper homeostasis, and mutations cause Menkes and Wilson diseases …
roles in cellular copper homeostasis, and mutations cause Menkes and Wilson diseases …
Flippase and scramblase for phosphatidylserine exposure
S Nagata, T Sakuragi, K Segawa - Current Opinion in Immunology, 2020 - Elsevier
Highlights•Phospholipid scramblases, responsible for the PtdSer-exposure in activated
platelets and apoptotic cells, were identified.•Distinct mechanisms mediate PtdSer-exposure …
platelets and apoptotic cells, were identified.•Distinct mechanisms mediate PtdSer-exposure …
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion
JM Whitlock, LV Chernomordik - Journal of Biological Chemistry, 2021 - ASBMB
Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a
common step, cell–cell fusion. Recent years have brought about considerable progress in …
common step, cell–cell fusion. Recent years have brought about considerable progress in …
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry
The outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has created
a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor …
a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor …
The role of phosphatidylserine on the membrane in immunity and blood coagulation
J Wang, C Yu, J Zhuang, W Qi, J Jiang, X Liu… - Biomarker …, 2022 - Springer
The negatively charged aminophospholipid, phosphatidylserine (PtdSer), is located in the
inner leaflet of the plasma membrane in normal cells, and may be exposed to the outer …
inner leaflet of the plasma membrane in normal cells, and may be exposed to the outer …
Phosphatidylserine transport in cell life and death
Phosphatidylserine (PS) is a negatively charged glycerophospholipid found mainly in the
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …