Droplet digital PCR of viral DNA/RNA, current progress, challenges, and future perspectives
AA Kojabad, M Farzanehpour… - Journal of Medical …, 2021 - Wiley Online Library
High‐throughput droplet‐based digital PCR (ddPCR) is a refinement of the conventional
polymerase chain reaction (PCR) methods. In ddPCR, DNA/RNA is encapsulated …
polymerase chain reaction (PCR) methods. In ddPCR, DNA/RNA is encapsulated …
[HTML][HTML] Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV
Y Kim, JL Anderson, SR Lewin - Cell host & microbe, 2018 - cell.com
Despite the success of antiretroviral therapy (ART), there is currently no HIV cure and
treatment is life long. HIV persists during ART due to long-lived and proliferating latently …
treatment is life long. HIV persists during ART due to long-lived and proliferating latently …
[HTML][HTML] The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo
OS Søgaard, ME Graversen, S Leth, R Olesen… - PLoS …, 2015 - journals.plos.org
Pharmacologically-induced activation of replication competent proviruses from latency in the
presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV …
presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV …
[HTML][HTML] In vivo suppression of HIV rebound by didehydro-cortistatin A, a “block-and-lock” strategy for HIV-1 treatment
HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency
establishment. We postulated a" block-and-lock" functional cure approach based on …
establishment. We postulated a" block-and-lock" functional cure approach based on …
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
Latency and ongoing replication have both been proposed to explain the drug-insensitive
human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy …
human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy …
Enhancing SIV-specific immunity in vivo by PD-1 blockade
Chronic immunodeficiency virus infections are characterized by dysfunctional cellular and
humoral antiviral immune responses,,. As such, immune modulatory therapies that enhance …
humoral antiviral immune responses,,. As such, immune modulatory therapies that enhance …
Microbial translocation, immune activation, and HIV disease
NR Klatt, NT Funderburg, JM Brenchley - Trends in microbiology, 2013 - cell.com
The advent of combination antiretroviral therapy (cART) has significantly improved the
prognosis of human immunodeficiency virus (HIV)-infected individuals. However, individuals …
prognosis of human immunodeficiency virus (HIV)-infected individuals. However, individuals …
[HTML][HTML] HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
The presence of latent reservoirs has prevented the eradication of human immunodeficiency
virus (HIV) from infected patients successfully treated with anti‐retroviral therapy. The …
virus (HIV) from infected patients successfully treated with anti‐retroviral therapy. The …
[图书][B] Viruses, plagues, and history: past, present, and future
MBA Oldstone - 2020 - books.google.com
More people were killed by smallpox during the twentieth century--over 300 million--than by
all of the wars of that period combined. In 1918 and 1919, influenza virus claimed over 50 …
all of the wars of that period combined. In 1918 and 1919, influenza virus claimed over 50 …
The challenge of viral reservoirs in HIV-1 infection
JN Blankson, D Persaud… - Annual review of …, 2002 - annualreviews.org
▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a
replication-competent form of the virus accumulates and persists with more stable kinetic …
replication-competent form of the virus accumulates and persists with more stable kinetic …