Treatment resistant schizophrenia: Clinical, biological, and therapeutic perspectives
FC Nucifora Jr, E Woznica, BJ Lee, N Cascella… - Neurobiology of …, 2019 - Elsevier
Abstract Treatment resistant schizophrenia (TRS) refers to the significant proportion of
schizophrenia patients who continue to have symptoms and poor outcomes despite …
schizophrenia patients who continue to have symptoms and poor outcomes despite …
Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity
J Hall, S Trent, KL Thomas, MC O'Donovan… - Biological psychiatry, 2015 - Elsevier
Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …
schizophrenia: a polygenic component of risk mediated through multiple common risk …
[HTML][HTML] An examination of polygenic score risk prediction in individuals with first-episode psychosis
Abstract Background Polygenic risk scores (PRSs) have successfully summarized genome-
wide effects of genetic variants in schizophrenia with significant predictive power. In a …
wide effects of genetic variants in schizophrenia with significant predictive power. In a …
Recent genetic findings in schizophrenia and their therapeutic relevance
PJ Harrison - Journal of psychopharmacology, 2015 - journals.sagepub.com
Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …
Neurodevelopment, GABA system dysfunction, and schizophrenia
MJ Schmidt, K Mirnics - Neuropsychopharmacology, 2015 - nature.com
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …
Bleuler began documenting their findings. However, large clinical research efforts in recent …
[HTML][HTML] Genes associated with gray matter volume alterations in schizophrenia
Y Ji, X Zhang, Z Wang, W Qin, H Liu, K Xue, J Tang… - Neuroimage, 2021 - Elsevier
Although both schizophrenia and gray matter volume (GMV) show high heritability, however,
genes accounting for GMV alterations in schizophrenia remain largely unknown. Based on …
genes accounting for GMV alterations in schizophrenia remain largely unknown. Based on …
Autism risk across generations: a population-based study of advancing grandpaternal and paternal age
EM Frans, S Sandin, A Reichenberg… - JAMA …, 2013 - jamanetwork.com
Importance Advancing paternal age has been linked to autism. Objective To further expand
knowledge about the association between paternal age and autism by studying the effect of …
knowledge about the association between paternal age and autism by studying the effect of …
[HTML][HTML] Glutamate in schizophrenia: Neurodevelopmental perspectives and drug development
Research into the neurobiological processes that may lead to the onset of schizophrenia
places growing emphasis on the glutamatergic system and brain development. Preclinical …
places growing emphasis on the glutamatergic system and brain development. Preclinical …
[HTML][HTML] The role of prefrontal catecholamines in attention and working memory
KL Clark, B Noudoost - Frontiers in neural circuits, 2014 - frontiersin.org
While much progress has been made in identifying the brain regions and neurochemical
systems involved in the cognitive processes disrupted in mental illnesses, to date, the level …
systems involved in the cognitive processes disrupted in mental illnesses, to date, the level …
Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia
A Hoerder-Suabedissen… - Proceedings of the …, 2013 - National Acad Sciences
The subplate zone is a highly dynamic transient sector of the developing cerebral cortex that
contains some of the earliest generated neurons and the first functional synapses of the …
contains some of the earliest generated neurons and the first functional synapses of the …