Recent development and biomedical applications of decellularized extracellular matrix biomaterials
Decellularized matrix (dECM) is isolated extracellular matrix of tissues from its original
inhabiting cells, which has emerged as a promising natural biomaterial for tissue …
inhabiting cells, which has emerged as a promising natural biomaterial for tissue …
Modulating the foreign body response of implants for diabetes treatment
Diabetes Mellitus is a group of diseases characterized by high blood glucose levels due to
patients' inability to produce sufficient insulin. Current interventions often require implants …
patients' inability to produce sufficient insulin. Current interventions often require implants …
[HTML][HTML] Polymeric approaches to reduce tissue responses against devices applied for islet-cell encapsulation
Immunoisolation of pancreatic islets is a technology in which islets are encapsulated in
semipermeable but immunoprotective polymeric membranes. The technology allows for …
semipermeable but immunoprotective polymeric membranes. The technology allows for …
[HTML][HTML] Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …
[HTML][HTML] Cell microencapsulation technologies for sustained drug delivery: Latest advances in efficacy and biosafety
TB Lopez-Mendez, E Santos-Vizcaino… - Journal of Controlled …, 2021 - Elsevier
The development of cell microencapsulation systems began several decades ago. However,
today few systems have been tested in clinical trials. For this reason, in the last years …
today few systems have been tested in clinical trials. For this reason, in the last years …
[HTML][HTML] Extracellular matrix inclusion in immunoisolating alginate-based microcapsules promotes longevity, reduces fibrosis, and supports function of islet allografts in …
R Kuwabara, T Qin, LA Llacua, S Hu, MV Boekschoten… - Acta Biomaterialia, 2023 - Elsevier
Immunoisolation of pancreatic-islets in alginate-microcapsules is applied to treat diabetes.
However, long-term islet function is limited, which might be due to damaged and lack of …
However, long-term islet function is limited, which might be due to damaged and lack of …
[HTML][HTML] Proteome-wide and matrisome-specific alterations during human pancreas development and maturation
The extracellular matrix (ECM) is unique to each tissue and capable of guiding cell
differentiation, migration, morphology, and function. The ECM proteome of different …
differentiation, migration, morphology, and function. The ECM proteome of different …
ECM-based bioactive microencapsulation significantly improves islet function and graft performance
Microencapsulation is a promising strategy to prolong the survival and function of
transplanted pancreatic islets for diabetes therapy, albeit its translation has been impeded …
transplanted pancreatic islets for diabetes therapy, albeit its translation has been impeded …
[HTML][HTML] Subcutaneous device-free islet transplantation
X Zhou, Z Xu, Y You, W Yang, BZ Feng… - Frontiers in …, 2023 - frontiersin.org
Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it
affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is …
affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is …
[HTML][HTML] Therapeutic strategies for modulating the extracellular matrix to improve pancreatic islet function and survival after transplantation
Abstract Purposes of Review Extracellular matrix (ECM) components modulate the
interaction between pancreatic islet cells. During the islet isolation prior to transplantation as …
interaction between pancreatic islet cells. During the islet isolation prior to transplantation as …