[HTML][HTML] Role of FGFR3 in bladder cancer: Treatment landscape and future challenges

CM Ascione, F Napolitano, D Esposito… - Cancer Treatment …, 2023 - Elsevier
Bladder cancer is a heterogeneous malignancy and is responsible for approximately 3.2%
of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors …

Progress in systemic therapy for advanced-stage urothelial carcinoma

R Nadal, BP Valderrama, J Bellmunt - Nature Reviews Clinical …, 2024 - nature.com
Despite recent advances, advanced-stage urothelial carcinoma (aUC) remains incurable,
with 5-year survival rates of approximately 10%. Platinum-based chemotherapy has a major …

Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study

AO Siefker-Radtke, A Necchi, SH Park… - The Lancet …, 2022 - thelancet.com
Background Erdafitinib, a pan-fibroblast growth factor receptor (FGFR) tyrosine kinase
inhibitor, was shown to be clinically active and tolerable in patients with advanced urothelial …

[HTML][HTML] Tyrosine kinase inhibitors

RJ Thomson, M Moshirfar, Y Ronquillo - StatPearls [Internet], 2023 - ncbi.nlm.nih.gov
Tyrosine Kinase Inhibitors - StatPearls - NCBI Bookshelf US flag An official website of the
United States government Here's how you know NIH NLM Logo Access keys NCBI Homepage …

Adverse events in patients with advanced urothelial carcinoma treated with erdafitinib: a retrospective pharmacovigilance study

T Yuan, F Li, Y Hou, H Guo - Frontiers in Pharmacology, 2023 - frontiersin.org
Purpose: On 12 April 2019, erdafitinib gained the first FDA approval as the second-line
treatment for adult patients with locally advanced or metastatic urothelial cancer following …

Pioneering electrochemical detection unveils erdafitinib: a breakthrough in anticancer agent determination

MH Yildir, AA Genc, N Erk, W Bouali, N Bugday… - Microchimica Acta, 2024 - Springer
The successful fabrication is reported of highly crystalline Co nanoparticles interconnected
with zeolitic imidazolate framework (ZIF-12)-based amorphous porous carbon using the …

The evolving treatment landscape of metastatic urothelial cancer

G Roviello, M Santoni, GP Sonpavde… - Nature Reviews …, 2024 - nature.com
Cisplatin-based chemotherapy is currently the first-line standard of care for patients with
metastatic urothelial cancer (mUC); however, up to 50% of patients are ineligible for …

How Do Molecular Classifications Affect the Neoadjuvant Treatment of Muscle-Invasive Urothelial Carcinoma?

N Conci, E Tassinari, V Tateo, M Rosellini… - Molecular Diagnosis & …, 2024 - Springer
Despite the significant improvements in the field of oncological treatments in recent
decades, and the advent of targeted therapies and immunotherapy, urothelial carcinoma of …

Risk factors for disease severity and increased medical resource utilization in respiratory syncytial virus (+) hospitalized children: A descriptive study conducted in four …

M Proesmans, A Rector, E Keyaerts, Y Vandendijck… - Plos one, 2022 - journals.plos.org
Background We aimed to provide regional data on clinical symptoms, medical resource
utilization (MRU), and risk factors for increased MRU in hospitalized respiratory syncytial …

Pyrazole: An important core in many marketed and clinical drugs

H Zhai, S Zhang, M Ampomah-Wireko, H Wang… - Russian Journal of …, 2022 - Springer
In recent years, increasing research attention has been directed to structurally diverse
pyrazole derivatives, many of which have become commercially available drugs with …