Nattokinase (NK, also known as subtilisin NAT)(EC 3.4. 21.62) is one of the most
considerable extracellular enzymes produced by Bacillus subtilis natto. The main interest …

Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots,
which are the primary causative agents in cardiovascular diseases. Developing safe …

With the dramatic increase in mortality of cardiovascular diseases (CVDs) caused by
thrombus, this has sparked an interest in seeking more effective thrombolytic drugs or …

The past several decades have seen the development of many controlled-release
preparations featuring constant release rates to maintain drug concentrations in the human …

This study is undertaken to design a novel nano-sized delivery system of tissue-type
plasminogen activator (t-PA) which has a suppressed thrombolytic activity of t-PA, but …

Nattokinase is a thrombolytic enzyme obtained from Japanese traditional food natto for
prevention and cure of thrombosis-related cardiovascular diseases. However, the …

Nattokinase (NK) is a serine protease of the subtilisin family; as a potent fibrinolytic enzyme,
it is potentially useful for thrombosis therapy. For NK to be applied as an oral medicine for …

Nattokinase is a thrombolytic drug that is more advantageous than urokinase, streptokinase,
and tissue plasminogen activator because of its low price, high efficiency, and nontoxic side …

This study presents a novel and integrated preparation technology for nattokinase functional
food, including strain screening, fermentation, separation, and encapsulation. To rapidly …

Thrombus-related diseases have a high mortality rate and are seriously threatening human
life and health. Nattokinase (NK), which has a strong thrombolytic effect, can treat thrombotic …