The majority of diseases' biomarkers are enzymes, and the regulation of enzymes is
fundamental but crucial. Biological system disorders and diseases can result from abnormal …

Carboxylesterases (CEs) are members of prominent esterase, and as their name imply, they
catalyze the cleavage of ester linkages. By far, a considerable number of novel CEs have …

Microneedles with insulin-loaded glucose-responsive particles are promising to control the
blood glucose levels of diabetic patients. In particular, the long-term usage of these …

Human carboxylesterases (CESs) are serine hydrolases that are responsible for the phase I
metabolism of an assortment of ester, amide, thioester, carbonate, and carbamate …

Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-
11) in the treatment against colorectal cancer and also has some relationship with the side …

Tracking carboxylesterases (CESs) through noninvasive and dynamic imaging is of great
significance for diagnosing and treating CES-related metabolic diseases. Herein, three …

This tutorial review provides a summary and discussion of recent advances in
chemosensors that fluorescently respond to the enzyme systems involved in Phase I …

Human carboxylesterase 2A (hCES2A) is an important endoplasmic reticulum (ER)-resident
enzyme that is responsible for the hydrolytic metabolism or activation of numerous ester …

Carboxylesterase (CE) localized in the lumen of the endoplasmic reticulum (ER) hydrolyzes
many prodrugs to exert therapeutic effect, such as anticoagulant clopidogrel and …

Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …