[HTML][HTML] Superfamily II helicases: the potential therapeutic target for cardiovascular diseases

T Fang, X Wang, N Huangfu - Frontiers in Cardiovascular Medicine, 2023 - ncbi.nlm.nih.gov
Cardiovascular diseases (CVDs) still maintain high morbidity and mortality globally.
Helicases, a unique class of enzymes, are extensively implicated in the processes of nucleic …

[HTML][HTML] Superfamily II helicases: the potential therapeutic target for cardiovascular diseases

T Fang, X Wang, N Huangfu - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Cardiovascular diseases (CVDs) still maintain high morbidity and mortality globally.
Helicases, a unique class of enzymes, are extensively implicated in the processes of nucleic …

[HTML][HTML] The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families

Y Zhong, H Moghaddas Sani, BP Paudel… - Nature …, 2022 - nature.com
CHD4 is an essential, widely conserved ATP-dependent translocase that is also a broad
tumour dependency. In common with other SF2-family chromatin remodelling enzymes, it …

Identification of Hub Genes in Neuropathic Pain-induced Depression

CY Cui, MH Liu, J Mou, SJ Liao, Y Liu, Q Li… - Current …, 2023 - ingentaconnect.com
Introduction: Numerous clinical data and animal models demonstrate that many patients with
neuropathic pain suffer from concomitant depressive symptoms. Methods: Massive evidence …

CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease

M Jia, X Zou, S Yin, W Tian, Y Zhao… - Immunity …, 2022 - Wiley Online Library
Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the
nucleosome remodeling and deacetylation complex. It has been implicated in gene …

[PDF][PDF] Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation

ACF Ferreira, ACH Szeto, PA Clark, A Crisp, P Kozik… - Immunity, 2023 - cell.com
Type 2 immune responses are critical in tissue homeostasis, anti-helminth immunity, and
allergy. T helper 2 (Th2) cells produce interleukin-4 (IL-4), IL-5, and IL-13 from the type 2 …

[引用][C] Stability and change in epigenetic regulation of immune cells

J Scott‐Browne, HY Shih - Immunological Reviews, 2022 - Wiley Online Library
The cells within the immune system differentiate from a common precursor and need to be
poised for rapid function after foreign insult, without responding to self. This response must …