[HTML][HTML] Low-Density Lipoprotein Receptor-Related Protein 1 as a Potential Therapeutic Target in Alzheimer's Disease
S Petralla, M Panayotova, E Franchina, G Fricker… - Pharmaceutics, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease impacting the lives of
millions of people worldwide. The formation of amyloid β (Aβ) plagues in the brain is the …
millions of people worldwide. The formation of amyloid β (Aβ) plagues in the brain is the …
Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer's disease?
M Lozupone, BP Imbimbo, C Balducci… - Alzheimer's & …, 2023 - Wiley Online Library
Human apolipoprotein E (apoE) is a 299‐amino acid secreted glycoprotein binding
cholesterol and phospholipids, and with three common isoforms (APOE ε2, APOE ε3, and …
cholesterol and phospholipids, and with three common isoforms (APOE ε2, APOE ε3, and …
Impact of constipation on progression of Alzheimer's disease: A retrospective study
T Nakase, Y Tatewaki, B Thyreau… - CNS Neuroscience …, 2022 - Wiley Online Library
Abstract Background and Purpose In terms of the gut‐brain axis, constipation has been
considered to be an important factor of neurodegenerative diseases, although the exact …
considered to be an important factor of neurodegenerative diseases, although the exact …
27-Hydroxycholesterol-induced dysregulation of cholesterol metabolism impairs learning and memory ability in ApoE ε4 transgenic mice
Y Wang, L Hao, T Wang, W Liu, L Wang, M Ju… - International Journal of …, 2022 - mdpi.com
Dysregulated brain cholesterol metabolism is one of the characteristics of Alzheimer's
disease (AD). 27-Hydroxycholesterol (27-OHC) is a cholesterol metabolite that plays an …
disease (AD). 27-Hydroxycholesterol (27-OHC) is a cholesterol metabolite that plays an …
Exome-wide analysis reveals role of LRP1 and additional novel loci in cognition
S Chakraborty, B Kahali - Human Genetics and Genomics Advances, 2023 - cell.com
Cognitive functioning is heritable, with metabolic risk factors known to accelerate age-
associated cognitive decline. Identifying genetic underpinnings of cognition is thus crucial …
associated cognitive decline. Identifying genetic underpinnings of cognition is thus crucial …
Seed-based morphometry of nodes in the default mode network among patients with Alzheimer's disease in Klang Valley, Malaysia
NH Mohad Azmi, S Suppiah, NS Nabila Ibrahim… - medRxiv, 2023 - medrxiv.org
The default mode network (DMN) is a prominent neural network in the human brain that
exhibits a substantial association with Alzheimer's disease (AD). Functional connectivity …
exhibits a substantial association with Alzheimer's disease (AD). Functional connectivity …
Default mode network perturbations in Alzheimer's disease: an fMRI study in Klang Valley, Malaysia
NHM Azmi, S Suppiah, NSN Ibrahim… - Neuroscience …, 2024 - dr.ntu.edu.sg
The default mode network (DMN) is a large neural network that has a significant correlation
with Alzheimer's disease (AD). Grey matter volume (GMV) and functional connectivity (FC) …
with Alzheimer's disease (AD). Grey matter volume (GMV) and functional connectivity (FC) …
Low-density lipoprotein receptor-related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson's disease
H Luo, C Peng, C Wu, C Liu, Q Li, S Yu, J Liu… - Neural Regeneration … - journals.lww.com
Abstract α-Synuclein accumulation and transmission are vital to the pathogenesis of
Parkinson's disease, although the mechanisms underlying misfolded α-synuclein …
Parkinson's disease, although the mechanisms underlying misfolded α-synuclein …