The role of interleukin-22 in lung health and its therapeutic potential for COVID-19

S Fang, D Ju, Y Lin, W Chen - Frontiers in immunology, 2022 - frontiersin.org
Although numerous clinical trials have been implemented, an absolutely effective treatment
against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has …

[HTML][HTML] IL-22: there is a gap in our knowledge

LA Zenewicz - Immunohorizons, 2018 - journals.aai.org
IL-22 is a critical cytokine in modulating tissue responses during inflammation. IL-22 is
upregulated in many chronic inflammatory diseases, making IL-22 biology a potentially …

Gut microbiota-mediated protection against influenza virus subtype H9N2 in chickens is associated with modulation of the innate responses

A Yitbarek, K Taha-Abdelaziz, DC Hodgins, L Read… - Scientific reports, 2018 - nature.com
Commensal gut microbiota plays an important role in health and disease. The current study
was designed to assess the role of gut microbiota of chickens in the initiation of antiviral …

Commensal Lactobacillus controls immune tolerance during acute liver injury in mice

N Nakamoto, T Amiya, R Aoki, N Taniki, Y Koda… - Cell reports, 2017 - cell.com
Gut-derived microbial antigens trigger the innate immune system during acute liver injury.
During recovery, regulatory immunity plays a role in suppressing inflammation; however, the …

Intestinal microbiome profiles in broiler chickens raised without antibiotics exhibit altered microbiome dynamics relative to conventionally raised chickens

SH Kairmi, K Abdelaziz, H Spahany, J Astill, D Trott… - Plos one, 2024 - journals.plos.org
The present study was undertaken to profile and compare the cecal microbial communities
in conventionally (CONV) grown and raised without antibiotics (RWA) broiler chickens …

[HTML][HTML] Role of the intestinal microbiota in the immunomodulation of influenza virus infection

CJ Chen, GH Wu, RL Kuo, SR Shih - Microbes and Infection, 2017 - Elsevier
Prevention and treatment measures against influenza virus infection remain limited, and
alternative host protection strategies are badly needed. In this review, we discuss the …

Distinct expression patterns of interleukin-22 receptor 1 on blood hematopoietic cells in SARS-CoV-2 infection

N Albayrak, C Orte Cano, S Karimi, D Dogahe… - Frontiers in …, 2022 - frontiersin.org
The new pandemic virus SARS-CoV-2 is characterized by uncontrolled hyper-inflammation
in severe cases. As the IL-22/IL-22R1 axis was reported to be involved in inflammation …

Susceptibility of porcine IPEC-J2 intestinal epithelial cells to infection with porcine deltacoronavirus (PDCoV) and serum cytokine responses of gnotobiotic pigs to …

K Jung, A Miyazaki, H Hu, LJ Saif - Veterinary microbiology, 2018 - Elsevier
The porcine small intestinal epithelial cell line, IPEC-J2, is useful to characterize the
interactions of enterocytes with enteric viruses in vitro. We investigated whether IPEC-J2 …

The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis

AA Sattar, A Qaiser, H Kausar, S Aqil… - Frontiers in …, 2024 - frontiersin.org
Many studies have investigated the antiviral activity of cytokines, including interleukin-6 (IL-
6), interleukin-22 (IL-22), interleukin-32 gamma (IL-32γ), and interferon-lambda (IFN-λ) in …

Interleukin-22 immunotherapy during severe influenza enhances lung tissue integrity and reduces secondary bacterial systemic invasion

A Barthelemy, V Sencio, D Soulard… - Infection and …, 2018 - Am Soc Microbiol
Severe bacterial (pneumococcal) infections are commonly associated with influenza and are
significant contributors to the excess morbidity and mortality of influenza. Disruption of lung …