Glucose metabolism in mitochondria through oxidative phosphorylation (OXPHOS) for
generation of adenosine triphosphate (ATP) is vital for cell function. However, reactive …

Diabetes (DM), especially type 2 diabetes (T2DM) has become one of the major diseases
severely threatening public health worldwide. Islet beta cell dysfunctions and peripheral …

Objectives The antidiabetic potential of caffeic acid in fructose/streptozotocin-induced type 2
diabetic rats was examined in this study. Methods Male Sprague-Dawley rats were supplied …

Rationale: Dysregulated purinergic signaling transduction plays important roles in the
pathogenesis of cardiovascular diseases. However, the role and mechanism of vascular …

There are increasing concerns on the rising cases of diabetes mellitus with type 2 diabetes
(T2D) being of major interest as well as the cost of its treatment. Plant phenolic compounds …

Objective This study investigated the antidiabetic effect of vanillin using in vitro, in silico, and
in vivo experimental models. Methodology Type 2 diabetes (T2D) was induced in male …

Progressive decline in pancreatic beta-cell function is central to the pathogenesis of type 2
diabetes (T2D). Here, we explore the relationship between the beta cell and its nutritional …

Transplantation of encapsulated islets in a bioartificial pancreas is a promising alternative to
free islet cell therapy to avoid immunosuppressive regimens. However, hypoxia, which can …

In pancreatic beta cells, mitochondrial metabolism controls glucose-stimulated insulin
secretion (GSIS) by ATP production, redox signaling, and calcium (Ca2+) handling …

Background: Purinergic signaling accounts for a complex network of receptors and
extracellular enzymes responsible for the generation, recognition and degradation of …