[HTML][HTML] Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption …

F Gervasi, F Pojero - Biomedicines, 2024 - mdpi.com
The fact that the Mediterranean diet could represent a source of natural compounds with
cancer-preventive and therapeutic activity has been the object of great interest, especially …

Oncogenic Pathways and Targeted Therapies in Ovarian Cancer

C Lliberos, G Richardson, A Papa - Biomolecules, 2024 - mdpi.com
Epithelial ovarian cancer (EOC) is one of the most aggressive forms of gynaecological
malignancies. Survival rates for women diagnosed with OC remain poor as most patients …

[HTML][HTML] The Role of Glutathione Transferase Omega-Class Variant Alleles in Individual Susceptibility to Ovarian Cancer

P Simic, V Coric, I Pljesa, A Savic-Radojevic… - International Journal of …, 2024 - mdpi.com
The tumor microenvironment is affected by reactive oxygen species and has been
suggested to have an important role in ovarian cancer (OC) tumorigenesis. The role of …

Immunomodulating Sonocatalytic Nanoagents with Dual‐Functional Ir‐N Centers and Narrow Bandgap for Reversing Immunosuppression and Potentiating Ovarian …

X Huang, H Zhou, N Lv, Z Zhao, T Tian… - Advanced Functional …, 2024 - Wiley Online Library
The heterogeneity and immunosuppression microenvironment of ovarian cancer seriously
restrict the efficiency of monomodal treatment. Emerging multimodal therapy strategies …

Multi‐Material Digital Light Processing (DLP) Bioprinting of Heterogeneous Hydrogel Constructs with Perfusable Networks

M Yang, L Chu, Y Zhuang, C Qi, S Meng… - Advanced Functional …, 2024 - Wiley Online Library
The challenges of replicating the complex mechanical and structural diversity of natural
tissues in vitro by leveraging multi‐material digital light processing (DLP) bioprinting are …

[HTML][HTML] FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation

X Xu, X Zhuang, H Yu, P Li, X Li, H Lin, J Teoh… - Theranostics, 2024 - ncbi.nlm.nih.gov
Background: The therapeutic benefits of targeting follicle-stimulating hormone (FSH)
receptor in treatment of ovarian cancer are significant, whereas the role of FSH in ovarian …

Deguelin Restores Paclitaxel Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells via Inhibition of the EGFR Signaling Pathway

S Bae, S Bae, HS Kim, YJ Lim, G Kim… - Cancer Management …, 2024 - Taylor & Francis
Background Ovarian cancer is one of women's malignancies with the highest mortality
among gynecological cancers. Paclitaxel is used in first-line ovarian cancer chemotherapy …

A Stem-like Patient-Derived Ovarian Cancer Model of Platinum Resistance Reveals Dissociation of Stemness and Resistance

T Suzuki, A Conant, Y Jung, R Bax… - International Journal of …, 2024 - mdpi.com
To understand chemoresistance in the context of cancer stem cells (CSC), a cisplatin
resistance model was developed using a high-grade serous ovarian cancer patient-derived …

Antibody–Drug Conjugates: Advancing from Magic Bullet to Biological Missile

AC Veneziani, S Sneha, AM Oza - Clinical Cancer Research, 2024 - AACR
Precision drug development is focusing on targeting tumor cell surface proteins for
therapeutic delivery, maximizing biomarker identified on-target damage to the tumor while …

Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance

M Overchuk, BP Rickard, J Tulino, X Tan… - Photochemistry and …, 2024 - Wiley Online Library
Resistance to platinum‐based chemotherapies remains a significant challenge in advanced‐
stage high‐grade serous ovarian carcinoma, and patients with malignant ascites face the …