Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …

Skeletal muscle is the largest organ in the body. Skeletal muscles are primarily
characterized by their mechanical activity required for posture, movement, and breathing …

Abstract (See the Editorial Commentary by Capeau, on pages 1127–9.) Background.
Human immunodeficiency virus (HIV)–infected patients may have a greater risk of …

Introduction: Efficient antiretroviral-treatment (ART) generally allows control of HIV infection.
However, persons-living-with-HIV (PLWH), when aging, present a high prevalence of …

Two of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral
persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly …

Although white AT can contribute to anti-infectious immune responses, it can also be
targeted and perturbed by pathogens. The AT's immune involvement is primarily due to …

Background Although some integrase strand transfer inhibitors (INSTIs) promote peripheral
and central adipose tissue/weight gain in people with human immunodeficiency virus …

A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …

Lipid droplets (LDs) are ubiquitous cellular organelles for lipid storage which are composed
of a neutral lipid core bounded by a protein decorated phospholipid monolayer. Although …

miRNAs are important regulators of biological processes in many tissues, including the
differentiation and function of brown and white adipocytes. The endoribonuclease dicer is a …