Current problems and future avenues in proteoliposome research

AM Amati, S Graf, S Deutschmann… - Biochemical Society …, 2020 - portlandpress.com
Membrane proteins (MPs) are the gatekeepers between different biological compartments
separated by lipid bilayers. Being receptors, channels, transporters, or primary pumps, they …

Challenges and opportunities in delivering oral peptides and proteins

H Peng, J Wang, J Chen, Y Peng, X Wang… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Rapid advances in bioengineering enable the use of complex proteins as
therapeutic agents to treat diseases. Compared with conventional small molecule drugs …

[HTML][HTML] The next-generation DNA vaccine platforms and delivery systems: Advances, challenges and prospects

B Lu, JM Lim, B Yu, S Song, P Neeli… - Frontiers in …, 2024 - frontiersin.org
Vaccines have proven effective in the treatment and prevention of numerous diseases.
However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such …

[HTML][HTML] Natural compounds in liposomal nanoformulations of potential clinical application in glioblastoma

L Piwowarczyk, DT Mlynarczyk, V Krajka-Kuźniak… - Cancers, 2022 - mdpi.com
Simple Summary Glioma is a type of cancer that is the most common primary brain tumor in
adults. The prognosis is often unfavorable despite early detection and treatment. Therefore …

Analyzing liposomal drug delivery systems in three-dimensional cell culture models using MALDI imaging mass spectrometry

JK Lukowski, EM Weaver, AB Hummon - Analytical chemistry, 2017 - ACS Publications
Cancer chemotherapeutics often fail to reach all diseased cells. To help solve this problem,
researchers are investigating novel drug delivery systems. Liposomes are an attractive …

[HTML][HTML] Application of lipid-based nanocarriers for antitubercular drug delivery: a review

AB Buya, BA Witika, AM Bapolisi, C Mwila… - Pharmaceutics, 2021 - mdpi.com
The antimicrobial drugs currently used for the management of tuberculosis (TB) exhibit poor
bioavailability that necessitates prolonged treatment regimens and high dosing frequency to …

Recent advancements in liposome-targeting strategies for the treatment of gliomas: a systematic review

J Li, T Tan, L Zhao, M Liu, Y You, Y Zeng… - ACS Applied Bio …, 2020 - ACS Publications
Malignant tumors represent some of the most intractable diseases that endanger human
health. A glioma is a tumor of the central nervous system that is characterized by severe …

[HTML][HTML] An insight into the risk factors of brain tumors and their therapeutic interventions

S Rasheed, K Rehman, MSH Akash - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Brain tumors are an abnormal growth of cells in the brain, also known as multifactorial
groups of neoplasm. Incidence rates of brain tumors increase rapidly, and it has become a …

Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA

Z Yu, X Zhang, X Pei, W Cao, J Ye, J Wang… - International Journal of …, 2021 - Elsevier
The tissue-specific targeted delivery and efficient cellular uptake of siRNAs are the main
obstacles to their clinical application. Antibody-siRNA-conjugates (ARCs) can deliver siRNA …

[HTML][HTML] Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases

Z Ma, B Zhang, Y Fan, M Wang, D Kebebe, J Li… - Biomedicine & …, 2019 - Elsevier
Liver diseases are clinically common and present a substantial public health issue. Many of
the currently available drugs for the treatment of liver diseases suffer from limitations that …