The receptor activator of NF-κB ligand (RANKL) induces various osteoclast-specific marker
genes during osteoclast differentiation mediated by mitogen-activated protein (MAP) kinase …

Background: The mitogen-activated protein (MAP) kinases are important signaling
molecules that participate in diverse cellular events and are potential targets for intervention …

Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has
progressed dramatically. The key advances include (1) identification of p38 MAP kinase …

The molecular mechanisms mediating stress-induced dysphoria in humans and conditioned
place aversion in rodents are unknown. Here, we show that repeated swim stress caused …

A novel homologue of p38 MAP kinase, called SAPK4, has been cloned which shares 61%
amino acid identity with p38 and is expressed predominantly in testes, pancreas and small …

Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature
senescence under sublethal oxidative stress, however underlying mechanism remains …

p38 MAPK is a Ser/Thr protein kinase activated by various inflammatory cytokines and a
variety of stress stimuli. It is involved in many physiological processes, including the …

This review article illustrates the growing use of azaindole derivatives as kinase inhibitors
and their contribution to drug discovery and innovation. The different protein kinases which …

Intestinal microbiota determine severity of myocardial infarction in rats. We determined
whether low molecular weight metabolites derived from intestinal microbiota and transported …

Summary Plasminogen activator inhibitor-1 (PAI-1) has a pro-tumorigenic function via its pro-
angiogenic and anti-apoptotic activities. Here, we demonstrate that PAI-1 promotes the …