Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer

K Li, H Shi, B Zhang, X Ou, Q Ma, Y Chen… - Signal transduction and …, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Myeloid-derived suppressor cells: a propitious road to clinic

A Grover, E Sanseviero, E Timosenko, DI Gabrilovich - Cancer discovery, 2021 - AACR
Myeloid-derived suppressor cells (MDSC) are important regulators of immune responses in
cancer. They represent a relatively stable form of pathologic activation of neutrophils and …

[HTML][HTML] Myeloid-derived suppressor cells in tumors: from mechanisms to antigen specificity and microenvironmental regulation

Y Yang, C Li, T Liu, X Dai, AV Bazhin - Frontiers in immunology, 2020 - frontiersin.org
Among the various immunological and non-immunological tumor-promoting activities of
myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a …

Myeloid-derived suppressor cells: immune-suppressive cells that impair antitumor immunity and are sculpted by their environment

S Ostrand-Rosenberg, C Fenselau - The Journal of Immunology, 2018 - journals.aai.org
Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid
cells that have potent immune-suppressive activity. Studies in both mice and humans have …

Targeting myeloid-derived suppressor cells to bypass tumor-induced immunosuppression

V Fleming, X Hu, R Weber, V Nagibin, C Groth… - Frontiers in …, 2018 - frontiersin.org
The immune system has many sophisticated mechanisms to balance an extensive immune
response. Distinct immunosuppressive cells could protect from excessive tissue damage …

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

L Deng, H Liang, B Burnette, M Beckett… - The Journal of …, 2014 - Am Soc Clin Investig
High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-
specific immunity, which enhances tumor control both locally and distantly. Unfortunately …

Coordinated regulation of myeloid cells by tumours

DI Gabrilovich, S Ostrand-Rosenberg… - Nature Reviews …, 2012 - nature.com
Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and
are a collection of distinct cell populations with many diverse functions. The three groups of …

Myeloid-derived suppressor cells: critical cells driving immune suppression in the tumor microenvironment

KH Parker, DW Beury, S Ostrand-Rosenberg - Advances in cancer …, 2015 - Elsevier
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …

Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions

A Filatenkov, J Baker, AMS Mueller, J Kenkel… - Clinical Cancer …, 2015 - AACR
Purpose: The goals of the study were to elucidate the immune mechanisms that contribute to
desirable complete remissions of murine colon tumors treated with single radiation dose of …

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

H Mohammadpour, CR MacDonald… - The Journal of …, 2019 - Am Soc Clin Investig
Catecholamines released by sympathetic nerves can activate adrenergic receptors present
on nearly every cell type, including myeloid-derived suppressor cells (MDSCs). Using in …