[HTML][HTML] Pharmacogenomics of CYP2C9: Functional and Clinical Considerations†
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
[HTML][HTML] Genome interpretation using in silico predictors of variant impact
Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …
personalized therapeutic opportunities. Clinical associations and laboratory experiments …
[HTML][HTML] Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors
D Lagorce, D Douguet, MA Miteva, BO Villoutreix - Scientific reports, 2017 - nature.com
The modulation of PPIs by low molecular weight chemical compounds, particularly by orally
bioavailable molecules, would be very valuable in numerous disease indications. However …
bioavailable molecules, would be very valuable in numerous disease indications. However …
[HTML][HTML] Recommendations for clinical CYP2C9 genotyping allele selection: a joint recommendation of the Association for Molecular Pathology and College of …
The goals of the Association for Molecular Pathology Pharmacogenomics (PGx) Working
Group of the Association for Molecular Pathology Clinical Practice Committee are to define …
Group of the Association for Molecular Pathology Clinical Practice Committee are to define …
Recent Advances of DprE1 Inhibitors against Mycobacterium tuberculosis: Computational Analysis of Physicochemical and ADMET Properties
PSM Amado, C Woodley, MLS Cristiano, PM O'Neill - ACS omega, 2022 - ACS Publications
Decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) is a critical flavoenzyme in
Mycobacterium tuberculosis, catalyzing a vital step in the production of lipoarabinomannan …
Mycobacterium tuberculosis, catalyzing a vital step in the production of lipoarabinomannan …
[HTML][HTML] Pharmacogenetics of human sulfotransferases and impact of amino acid exchange on Phase II drug metabolism
Sulfotransferases (SULTs) are Phase II drug-metabolizing enzymes (DMEs) catalyzing the
sulfation of a variety of endogenous compounds, natural products, and drugs. Various drugs …
sulfation of a variety of endogenous compounds, natural products, and drugs. Various drugs …
Analysis of protein missense alterations by combining sequence‐and structure‐based methods
A Gyulkhandanyan, AR Rezaie… - … Genetics & Genomic …, 2020 - Wiley Online Library
Background Different types of in silico approaches can be used to predict the phenotypic
consequence of missense variants. Such algorithms are often categorized as sequence …
consequence of missense variants. Such algorithms are often categorized as sequence …
The influence of CYP2C19 polymorphisms on voriconazole trough concentrations: Systematic review and meta‐analysis
Y Zhang, K Hou, F Liu, X Luo, S He, L Hu, C Yang… - Mycoses, 2021 - Wiley Online Library
Background Voriconazole primary metabolism is catalysed by CYP2C19. A large variability
of trough concentrations in patients with invasive fungal infection treated with voriconazole …
of trough concentrations in patients with invasive fungal infection treated with voriconazole …
Pharmacogenomics of triazole antifungal agents: implications for safety, tolerability and efficacy
JR Amsden, PO Gubbins - Expert opinion on drug metabolism & …, 2017 - Taylor & Francis
Introduction: Triazole antifungal agents are prescribed to treat invasive fungal infections in
neutropenic and non-neutropenic patients. These antifungal agents are substrates and …
neutropenic and non-neutropenic patients. These antifungal agents are substrates and …
[HTML][HTML] Exploring the molecular structure, vibrational spectroscopic, quantum chemical calculation and molecular docking studies of curcumin: A potential PI3K/AKT …
The IUPAC name of curcumin is (1E, 6E)-1, 7-Bis (4-hydroxy-3methoxyphenyl) hepta-1, 6-e-
3, 5-dione (7B3M5D) and is characterized by spectroscopic profiling with FT-IR and FT …
3, 5-dione (7B3M5D) and is characterized by spectroscopic profiling with FT-IR and FT …