Lung cancer LDCT screening and mortality reduction—evidence, pitfalls and future perspectives

M Oudkerk, SY Liu, MA Heuvelmans… - Nature reviews Clinical …, 2021 - nature.com
In the past decade, the introduction of molecularly targeted agents and immune-checkpoint
inhibitors has led to improved survival outcomes for patients with advanced-stage lung …

Progress and prospects of early detection in lung cancer

S Blandin Knight, PA Crosbie, H Balata… - Open …, 2017 - royalsocietypublishing.org
Lung cancer is the leading cause of cancer-related death in the world. It is broadly divided
into small cell (SCLC, approx. 15% cases) and non-small cell lung cancer (NSCLC, approx …

Practical considerations for the use of circulating tumor DNA in the treatment of patients with cancer: a narrative review

MG Krebs, U Malapelle, F André, L Paz-Ares… - JAMA …, 2022 - jamanetwork.com
Importance Personalized medicine based on tumor profiling and identification of actionable
genomic alterations is pivotal in cancer management. Although tissue biopsy is still …

Screening for lung cancer: CHEST guideline and expert panel report

PJ Mazzone, GA Silvestri, S Patel, JP Kanne… - Chest, 2018 - Elsevier
Background Low-dose chest CT screening for lung cancer has become a standard of care in
the United States in the past few years, in large part due to the results of the National Lung …

UK Lung Cancer RCT Pilot Screening Trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening

JK Field, SW Duffy, DR Baldwin, DK Whynes… - Thorax, 2016 - thorax.bmj.com
Background Lung cancer screening using low-dose CT (LDCT) was shown to reduce lung
cancer mortality by 20% in the National Lung Screening Trial. Methods The pilot UK Lung …

Barriers to lung cancer screening engagement from the patient and provider perspective

GX Wang, TP Baggett, PV Pandharipande, ER Park… - Radiology, 2019 - pubs.rsna.org
Lung cancer remains the leading cause of cancer mortality in the United States. Lung cancer
screening (LCS) with low-dose CT reduces mortality among high-risk current and former …

Impact of low‐dose computed tomography (LDCT) screening on lung cancer‐related mortality

A Bonney, R Malouf, C Marchal… - Cochrane Database …, 2022 - cochranelibrary.com
Background Lung cancer is the most common cause of cancer‐related death in the world,
however lung cancer screening has not been implemented in most countries at a population …

Low‐dose computed tomography lung cancer screening: Clinical evidence and implementation research

HL Lancaster, MA Heuvelmans… - Journal of Internal …, 2022 - Wiley Online Library
Lung cancer causes more deaths than breast, cervical, and colorectal cancer combined.
Nevertheless, population‐based lung cancer screening is still not considered standard …

Screening for lung cancer: CHEST guideline and expert panel report

PJ Mazzone, GA Silvestri, LH Souter, TJ Caverly… - Chest, 2021 - Elsevier
Background Low-dose chest CT screening for lung cancer has become a standard of care in
the United States, in large part because of the results of the National Lung Screening Trial …

Lung screen uptake trial (LSUT): randomized controlled clinical trial testing targeted invitation materials

SL Quaife, M Ruparel, JL Dickson… - American journal of …, 2020 - atsjournals.org
Rationale: Low uptake of low-dose computed tomography (LDCT) lung cancer screening,
particularly by current smokers of a low socioeconomic position, compromises effectiveness …