[HTML][HTML] Natural products in drug discovery: advances and opportunities

AG Atanasov, SB Zotchev, VM Dirsch… - Nature reviews Drug …, 2021 - nature.com
Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Detection and analysis of chiral molecules as disease biomarkers

Y Liu, Z Wu, DW Armstrong, H Wolosker… - Nature Reviews …, 2023 - nature.com
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Proteomics: technologies and their applications

B Aslam, M Basit, MA Nisar, M Khurshid… - Journal of …, 2016 - academic.oup.com
Proteomics involves the applications of technologies for the identification and quantification
of overall proteins present content of a cell, tissue or an organism. It supplements the other …

Interactions between medical plant-derived bioactive compounds: focus on antimicrobial combination effects

N Vaou, E Stavropoulou, C Voidarou, Z Tsakris… - Antibiotics, 2022 - mdpi.com
It is accepted that the medicinal use of complex mixtures of plant-derived bioactive
compounds is more effective than purified bioactive compounds due to beneficial …

[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review

AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …

Plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance

HMA AlSheikh, I Sultan, V Kumar, IA Rather… - Antibiotics, 2020 - mdpi.com
The unprecedented use of antibiotics that led to development of resistance affect human
health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases …

Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics

T Cajka, O Fiehn - Analytical chemistry, 2016 - ACS Publications
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …

Identification of small molecules using accurate mass MS/MS search

T Kind, H Tsugawa, T Cajka, Y Ma, Z Lai… - Mass spectrometry …, 2018 - Wiley Online Library
Tandem mass spectral library search (MS/MS) is the fastest way to correctly annotate MS/MS
spectra from screening small molecules in fields such as environmental analysis, drug …

Bioactivity-based molecular networking for the discovery of drug leads in natural product bioassay-guided fractionation

LF Nothias, M Nothias-Esposito… - Journal of natural …, 2018 - ACS Publications
It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …

The genome of homosporous maidenhair fern sheds light on the euphyllophyte evolution and defences

Y Fang, X Qin, Q Liao, R Du, X Luo, Q Zhou, Z Li… - Nature Plants, 2022 - nature.com
Euphyllophytes encompass almost all extant plants, including two sister clades, ferns and
seed plants. Decoding genomes of ferns is the key to deep insight into the origin of …