[HTML][HTML] Natural products in drug discovery: advances and opportunities
AG Atanasov, SB Zotchev, VM Dirsch… - Nature reviews Drug …, 2021 - nature.com
Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …
Detection and analysis of chiral molecules as disease biomarkers
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …
Proteomics: technologies and their applications
Proteomics involves the applications of technologies for the identification and quantification
of overall proteins present content of a cell, tissue or an organism. It supplements the other …
of overall proteins present content of a cell, tissue or an organism. It supplements the other …
Interactions between medical plant-derived bioactive compounds: focus on antimicrobial combination effects
N Vaou, E Stavropoulou, C Voidarou, Z Tsakris… - Antibiotics, 2022 - mdpi.com
It is accepted that the medicinal use of complex mixtures of plant-derived bioactive
compounds is more effective than purified bioactive compounds due to beneficial …
compounds is more effective than purified bioactive compounds due to beneficial …
[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review
AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …
therapeutic potential, and nowadays still represent an important pool for the identification of …
Plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance
The unprecedented use of antibiotics that led to development of resistance affect human
health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases …
health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases …
Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …
Identification of small molecules using accurate mass MS/MS search
Tandem mass spectral library search (MS/MS) is the fastest way to correctly annotate MS/MS
spectra from screening small molecules in fields such as environmental analysis, drug …
spectra from screening small molecules in fields such as environmental analysis, drug …
Bioactivity-based molecular networking for the discovery of drug leads in natural product bioassay-guided fractionation
LF Nothias, M Nothias-Esposito… - Journal of natural …, 2018 - ACS Publications
It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …
good bioassay results in the initial extract, the active compound (s) may not be isolated …
The genome of homosporous maidenhair fern sheds light on the euphyllophyte evolution and defences
Euphyllophytes encompass almost all extant plants, including two sister clades, ferns and
seed plants. Decoding genomes of ferns is the key to deep insight into the origin of …
seed plants. Decoding genomes of ferns is the key to deep insight into the origin of …