Shp2: A pleiotropic target at the interface of cancer and its microenvironment
NM Sodir, G Pathria, JI Adamkewicz, EH Kelley… - Cancer discovery, 2023 - AACR
The protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …
proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been …
Tyrosine phosphatase PTPN11/SHP2 in solid tumors - bull's eye for targeted therapy?
X Chen, SJ Keller, P Hafner, AY Alrawashdeh… - Frontiers in …, 2024 - frontiersin.org
Encoded by PTPN11, the Src-homology 2 domain-containing phosphatase 2 (SHP2)
integrates signals from various membrane-bound receptors such as receptor tyrosine …
integrates signals from various membrane-bound receptors such as receptor tyrosine …
[HTML][HTML] Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases
A Wang, Y Zhang, X Lv, G Liang - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Protein tyrosine phosphorylation is a post-translational modification that regulates protein
structure to modulate demic organisms' homeostasis and function. This physiological …
structure to modulate demic organisms' homeostasis and function. This physiological …
Comprehensive Analysis of NKX3. 2 in Liver Hepatocellular Carcinoma by Bigdata
AN Bae, J Kim, JH Park, JH Lee, E Choi - Medicina, 2023 - mdpi.com
Background and Objectives: The gene NKX3. 2 plays a role in determining cell fate during
development, and mutations of NKX3. 2 have been studied in relation to human skeletal …
development, and mutations of NKX3. 2 have been studied in relation to human skeletal …
[引用][C] Combine and conquer as a strategy to treat RAS-driven cancers
RA Jansen - 2024 - Utrecht University