Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2

CJ Peach, VW Mignone, MA Arruda… - International journal of …, 2018 - mdpi.com
Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

The biological functions and regulatory mechanisms of fatty acid binding protein 5 in various diseases

B Xu, L Chen, Y Zhan, KNS Marquez, L Zhuo… - Frontiers in cell and …, 2022 - frontiersin.org
In recent years, fatty acid binding protein 5 (FABP5), also known as fatty acid transporter,
has been widely researched with the help of modern genetic technology. Emerging …

Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential

P Liu, Y Mao, Y Xie, J Wei, J Yao - Stem Cell Research & Therapy, 2022 - Springer
Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials
of stem cells for liver disease shown that stem cells might be a potential therapeutic …

The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

JA Adetunji, KD Fasae, AI Awe, OK Paimo… - Heliyon, 2023 - cell.com
The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …

MiR-182-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-C

S Yan, H Wang, X Chen, C Liang, W Shang, L Wang… - Cancer letters, 2020 - Elsevier
MicroRNAs (miRNAs) are gene modulators essential for biological processes. However, the
precise functions of miRNAs in growth and development of colon cancer are still elusive. To …

Biology of cancer; from cellular and molecular mechanisms to developmental processes and adaptation

IG Motofei - Seminars in Cancer Biology, 2022 - Elsevier
Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

Dissecting the roles and clinical potential of YY1 in the tumor microenvironment

MN Li, JX Wei, CN Xue, XT Zhou, SP Chen… - Frontiers in …, 2023 - frontiersin.org
Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a
vital dual biological role in cancer as an oncogene or a tumor suppressor during …

The tubulin detyrosination cycle: function and enzymes

J Nieuwenhuis, TR Brummelkamp - Trends in cell biology, 2019 - cell.com
Microtubules are subjected to a variety of post-translational modifications (PTMs). The
combination of different α-and β-tubulin isoforms and PTMs are referred to as the tubulin …

Intestinal microcirculation and necrotizing enterocolitis: the vascular endothelial growth factor system

RM Bowker, X Yan, IG De Plaen - Seminars in Fetal and Neonatal Medicine, 2018 - Elsevier
Necrotizing enterocolitis (NEC), a leading cause of morbidity and mortality in preterm
neonates, is a devastating disease characterized by intestinal tissue inflammation and …

Antisense oligonucleotides targeting angiogenic factors as potential cancer therapeutics

BT Le, P Raguraman, TR Kosbar, S Fletcher… - … Therapy-Nucleic Acids, 2019 - cell.com
Cancer is one of the leading causes of death worldwide, and conventional cancer therapies
such as surgery, chemotherapy, and radiotherapy do not address the underlying molecular …