The discovery of progesterone (P4) and elucidation of the mechanisms of P4 action have an
important place in the history of endocrinology and reproduction. Circulating P4 …

The ovarian hormones estrogen and progesterone are master regulators of the development
and function of a broad spectrum of human tissues, including the breast, reproductive and …

Accumulating data suggest that metastatic dissemination often occurs early during tumour
formation, but the mechanisms of early metastatic spread have not yet been addressed …

Progesterone is critical for the establishment and the maintenance of pregnancy, both by its
endocrine and immunological effects. The genomic actions of progesterone are mediated by …

This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse
mammary gland that has been used extensively as an experimental model. Studies have led …

Human progesterone receptor (PR) contains a motif that interacts with the SH3 domain of
Src and mediates rapid activation of Src and downstream MAPK (Erk-1/-2) without relying on …

While induced F ox P 3+ T cells (i T reg cells) are promising cellular therapeutics to treat
inflammatory diseases, a limitation in utilizing i T reg cells prepared in vitro is their low …

Receptor of Activated NF-κB Ligand (RANKL) is implicated as one of a number of effector
molecules that mediate progesterone and prolactin signaling in the murine mammary …

Implantation and the establishment of pregnancy in mammals involves an intricate interplay
of hormones, cytokines, growth factors, proteins, lipids, ions and the extracellular matrix …

Pregnancy represents a unique immunological situation. Though paternal antigens
expressed by the conceptus are recognized by the immune system of the mother, the …