Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

All the symptoms and pathology of malaria are caused by the intraerythrocytic stages of the
Plasmodium parasite life cycle. Because Plasmodium parasites cannot replicate outside a …

Antibodies play major roles in immunity to malaria; however, a limited understanding of
mechanisms mediating protection is a major barrier to vaccine development. We have …

Background An understanding of the mechanisms mediating protective immunity against
malaria in humans is currently lacking, but critically important to advance the development of …

Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic and
incident infections. In the current study, we assess parasite kinetics and infectivity to …

The development of effective malaria vaccines and immune biomarkers of malaria is a high
priority for malaria control and elimination. Ags expressed by merozoites of Plasmodium …

An effective blood-stage vaccine against Plasmodium falciparum remains a research
priority, but the number of antigens that have been translated into multicomponent vaccines …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Robust tools for analysing gene function in Plasmodium parasites, which are the causative
agents of malaria, are being developed at an accelerating rate. Two decades after genetic …

Numerous efforts to understand the functional roles of antibodies demonstrated that they can
protect against malaria. However, it is unclear which antibody responses are the best …