[HTML][HTML] Oxidative stress in liver pathophysiology and disease
The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …
not only arise during metabolic functions but also during the biotransformation of …
[HTML][HTML] Metabolic hallmarks of hepatic stellate cells in liver fibrosis
Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …
[HTML][HTML] Role of immuno-inflammatory signals in liver ischemia-reperfusion injury
Ischemia reperfusion injury (IRI) is a major obstacle in liver resection and liver
transplantation. The initial step of IRI is mediated through ischemia which promotes the …
transplantation. The initial step of IRI is mediated through ischemia which promotes the …
Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models
D Ezhilarasan - Environmental Toxicology and Pharmacology, 2023 - Elsevier
Thioacetamide (TAA) undergoes bioactivation in the liver by the CYP450 2E1 enzyme,
resulting in the formation of TAA-S-oxide and TAA-S-dioxide. TAA-S-dioxide induces …
resulting in the formation of TAA-S-oxide and TAA-S-dioxide. TAA-S-dioxide induces …
Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways
Liver fibrosis is a pathological wound-healing response caused by chronic liver damage due
to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential …
to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential …
[HTML][HTML] Pathophysiology and treatment options for hepatic fibrosis: can it be completely cured?
A Khanam, PG Saleeb, S Kottilil - Cells, 2021 - mdpi.com
Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …
[HTML][HTML] NADPH oxidases connecting fatty liver disease, insulin resistance and type 2 diabetes: Current knowledge and therapeutic outlook
A Nascè, K Gariani, FR Jornayvaz, I Szanto - Antioxidants, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …
hepatocytes, is closely linked to insulin resistance and is the most frequent complication of …
Oxidative stress-induced liver damage and remodeling of the liver vasculature
P Banerjee, N Gaddam, V Chandler… - The American Journal of …, 2023 - Elsevier
As an organ critically important for targeting and clearing viruses, bacteria, and other foreign
material, the liver operates via immune-tolerant, anti-inflammatory mechanisms …
material, the liver operates via immune-tolerant, anti-inflammatory mechanisms …
[HTML][HTML] Remodeling of mitochondrial plasticity: the key switch from NAFLD/NASH to HCC
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and
the third-leading cause of cancer-related mortality. Currently, the global burden of …
the third-leading cause of cancer-related mortality. Currently, the global burden of …
Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury
Abstract Background & Aims The outcome of liver injury is dictated by factors that control the
accumulation of myofibroblastic (activated) hepatic stellate cells (MF‐HSCs) but therapies …
accumulation of myofibroblastic (activated) hepatic stellate cells (MF‐HSCs) but therapies …