The need for highly effective vaccines that induce robust and long-lasting immunity has
never been more apparent. However, for reasons that are still poorly understood, immune …

The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

The control over iron availability is crucial under homeostatic conditions and even more in
the case of an infection. This results from diverse properties of iron: first, iron is an important …

Children aged 0–19 years in sub-Saharan Africa bear a disproportionate proportion of the
global burden of communicable and non-communicable diseases. Significant public health …

The human immune system is a distributed system of specialized cell populations with
unique functions that collectively give rise to immune responses to infections and during …

The essential trace element iron regulates a wide range of biological processes in virtually
all living organisms. Because both iron deficiency and iron overload can lead to various …

Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …

The RTS, S vaccine has recently been recommended for implementation as a childhood
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …

Vaccination is one of medicine's greatest achievements; however, its full potential is
hampered by considerable variation in efficacy across populations and geographical …

Vaccines are one of the greatest successes of public health, preventing millions of cases of
disease and death in children each year. However, the efficacy of many vaccines can vary …