[PDF][PDF] CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1–positive regulator for tumor immune evasion
Regulation of tumoral PD-L1 expression is critical to advancing our understanding of tumor
immune evasion and the improvement of existing antitumor immunotherapies. Herein, we …
immune evasion and the improvement of existing antitumor immunotherapies. Herein, we …
[HTML][HTML] ATXN3 deubiquitinates YAP1 to promote tumor growth
S Wang, K Liu, X Han, Y Cheng, E Zhao… - American Journal of …, 2023 - ncbi.nlm.nih.gov
The ubiquitin-specific peptidase Ataxin-3 (ATXN3) has emerged as a potential oncogene in
a variety of human cancers. However, the molecular mechanisms underlying how ATXN3 …
a variety of human cancers. However, the molecular mechanisms underlying how ATXN3 …
The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases
A Potapenko, JM Davidson, A Lee… - Biochemical …, 2024 - portlandpress.com
Machado-Joseph disease (MJD) is a devastating and incurable neurodegenerative disease
characterised by progressive ataxia, difficulty speaking and swallowing. Consequently …
characterised by progressive ataxia, difficulty speaking and swallowing. Consequently …
Involvement of Ataxin-3 (ATXN3) in the malignant progression of pancreatic cancer via deubiquitinating HDAC6
X Wu, X Zhang, P Liu, Y Wang - Pancreatology, 2023 - Elsevier
Background Pancreatic cancer is a common digestive system cancer and one of the most
lethal malignancies worldwide. Ataxin-3 (ATXN3) protein is a deubiquitinating enzyme …
lethal malignancies worldwide. Ataxin-3 (ATXN3) protein is a deubiquitinating enzyme …
ubiquitin-modifying enzymes in thyroid cancer: Mechanisms and functions
X Xiong, BB Huang, Z Gan, W Liu, Y Xie, J Zhong… - Heliyon, 2024 - cell.com
Thyroid cancer is the most common malignant tumor of the endocrine system, and evidence
suggests that post-translational modifications (PTMs) and epigenetic alterations play an …
suggests that post-translational modifications (PTMs) and epigenetic alterations play an …
Integrative analysis of small non-coding RNAs predicts a piRNA/miRNA-CCND1/BRAF/HRH1/ATXN3 regulatory circuit that drives oncogenesis in glioblastoma
The high-grade astrocytoma, glioblastoma multiforme (GBM), is the most common primary
tumour of the brain, known for being aggressive and developing drug resistance. The non …
tumour of the brain, known for being aggressive and developing drug resistance. The non …
ATXN3 promotes proliferation, stemness and motility of clear cell renal cell carcinoma cells by regulating S100A8 ubiquitination
J Bai, J Han, J Fan, J Song, S Wang - Physiology International, 2023 - akjournals.com
Background Clear cell renal cell carcinoma (ccRCC) is a dominant subtype of kidney cancer
with a dismal outcome at advanced stages. Ataxin 3 (ATXN3) has been proven to play a …
with a dismal outcome at advanced stages. Ataxin 3 (ATXN3) has been proven to play a …
Seeking Therapies for Spinocerebellar Ataxia: From Gene Silencing to Systems-Based Approaches
R Powers, H Paulson, S Srinivasan - Trials for Cerebellar Ataxias: From …, 2023 - Springer
Recent progress has led to nucleotide-based gene silencing strategies as a potential
therapy for spinocerebellar ataxia type 3 (SCA3) and other hereditary ataxias. But recent …
therapy for spinocerebellar ataxia type 3 (SCA3) and other hereditary ataxias. But recent …
MJDs family members: Potential prognostic targets and immune-associated biomarkers in hepatocellular carcinoma
L Zhou, G Chen, T Liu, X Liu, C Yang, J Jiang - Frontiers in Genetics, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common gastrointestinal malignancies. It
is not easy to be diagnosed in the early stage and is prone to relapse, with a very poor …
is not easy to be diagnosed in the early stage and is prone to relapse, with a very poor …