G protein-coupled receptors (GPCRs) are involved in a vast majority of signal transduction
processes. Although they span the cell membrane, they have not been considered to be …

The cannabis plant exerts its pharmaceutical activity primarily by the binding of
cannabinoids to two G protein-coupled cannabinoid receptors, CB1 and CB2. The role that …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Astrocytes provide structural and metabolic support of neuronal tissue, but may also be
involved in shaping synaptic output. To further define the role of striatal astrocytes in …

G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.
Almost 20 years ago, GPCR activity was shown to be regulated by membrane potential in …

G protein–coupled receptors are known to play a key role in many cellular signal
transduction processes, including those mediating serotonergic signaling in the nervous …

Cannabinoids produce their characteristic effects mainly by binding to two types of G-protein
coupled receptors (GPCRs), the CB1 and CB2 cannabinoid receptors. The CB1 receptor is …

The dopamine D2 receptor (D2R) functions as an autoreceptor on dopaminergic cell bodies
and terminals and as a postsynaptic receptor on a variety of neurons in the central nervous …

Some signaling processes mediated by G protein-coupled receptors (GPCRs) are
modulated by membrane potential. In recent years, increasing evidence that GPCRs are …

Serotonin (5-HT) plays a central role in various brain functions via the activation of a family
of receptors, most of them G protein coupled receptors (GPCRs). 5-HT 1A receptor, the most …