A SARS-CoV-2-related virus from Malayan pangolin causes lung infection without severe disease in human ACE2-transgenic mice
MQ Liu, HF Lin, J Li, Y Chen, Y Luo, W Zhang… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT Coronavirus disease 2019 (COVID-19), which is caused by the novel
coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the most …
coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the most …
The Delta SARS-CoV-2 variant of concern induces distinct pathogenic patterns of respiratory disease in K18-hACE2 transgenic mice compared to the ancestral strain …
Compared to the original ancestral strain of SARS-CoV-2, the Delta variant of concern has
shown increased transmissibility and resistance toward COVID-19 vaccines and therapies …
shown increased transmissibility and resistance toward COVID-19 vaccines and therapies …
Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome …
C Cianfarini, L Hassler, J Wysocki, A Hassan… - Cells, 2024 - mdpi.com
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) utilizes angiotensin-
converting enzyme 2 (ACE2) as its main receptor for cell entry. We bioengineered a soluble …
converting enzyme 2 (ACE2) as its main receptor for cell entry. We bioengineered a soluble …
Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host …
CJ Thieulent, W Dittmar, UBR Balasuriya… - Msphere, 2023 - Am Soc Microbiol
Several models were developed to study the pathogenicity of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and …
syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and …
SARS-CoV-2 rapidly evolves lineage-specific phenotypic differences when passaged repeatedly in immune-naive mice
JDS Willett, A Gravel, I Dubuc, L Gudimard… - Communications …, 2024 - nature.com
The persistence of SARS-CoV-2 despite the development of vaccines and a degree of herd
immunity is partly due to viral evolution reducing vaccine and treatment efficacy. Serial …
immunity is partly due to viral evolution reducing vaccine and treatment efficacy. Serial …
Genomic and structural mechanistic insight to reveal the differential infectivity of omicron and other variants of concern
P Sharma, M Kumar, MK Tripathi, D Gupta… - Computers in Biology …, 2022 - Elsevier
Background The genome of SARS-CoV-2, is mutating rapidly and continuously challenging
the management and preventive measures adopted and recommended by healthcare …
the management and preventive measures adopted and recommended by healthcare …
Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2
KS Lee, BP Russ, TY Wong, AM Horspool, MT Winters… - IScience, 2022 - cell.com
Severe outcomes from SARS-CoV-2 infection are highly associated with preexisting
comorbid conditions like hypertension, diabetes, and obesity. We utilized the diet-induced …
comorbid conditions like hypertension, diabetes, and obesity. We utilized the diet-induced …
Evaluation of the neutralizing antibody STE90-C11 against SARS-CoV-2 delta infection and its recognition of other variants of concerns
L Abassi, F Bertoglio, Ž Mačak Šafranko, T Schirrmann… - Viruses, 2023 - mdpi.com
As of now, the COVID-19 pandemic has spread to over 770 million confirmed cases and
caused approximately 7 million deaths. While several vaccines and monoclonal antibodies …
caused approximately 7 million deaths. While several vaccines and monoclonal antibodies …
Virulence profiles of wild-type, P. 1 and Delta SARS-CoV-2 variants in K18-hACE2 transgenic mice
Y da Silva Santos, THM Gamon, MSP de Azevedo… - Viruses, 2023 - mdpi.com
Since December 2019, the world has been experiencing the COVID-19 pandemic caused
by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and we now face …
by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and we now face …
[HTML][HTML] Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice
KS Lee, NA Rader, OA Miller-Stump, M Cooper… - Vaccine, 2023 - Elsevier
As the COVID-19 pandemic transitions into endemicity, seasonal boosters are a plausible
reality across the globe. We hypothesize that intranasal vaccines can provide better …
reality across the globe. We hypothesize that intranasal vaccines can provide better …