Evaluation of in vivo lithium chloride effects as a GSK3-β inhibitor on human adipose derived stem cells differentiation into oligodendrocytes and re-myelination in an …

S Ghosouri, M Soleimani, M Bakhtiari… - Molecular Biology …, 2023 - Springer
Background The application of neuroprotective agents in combination with stem cells is
considered a potential effective treatment for multiple sclerosis (MS). Therefore, the effects of …

Chronic pain and cannabidiol in animal models: behavioral pharmacology and future perspectives

GK Silva-Cardoso, CRA Leite-Panissi - Cannabis and Cannabinoid …, 2023 - liebertpub.com
The incidence of chronic pain is around 8% in the general population, and its impact on
quality of life, mood, and sleep exceeds the burden of its causal pathology. Chronic pain is a …

[HTML][HTML] Korean Red Ginseng extract ameliorates demyelination by inhibiting infiltration and activation of immune cells in cuprizone-administrated mice

MJ Lee, JH Choi, TW Kwon, HS Jo, Y Ha… - Journal of Ginseng …, 2023 - Elsevier
Abstract Background Korean Red Ginseng (KRG), the steamed root of Panax ginseng, has
pharmacological activities for immunological and neurodegenerative disorders. But, the role …

Modulating the ubiquitin–proteasome system: a therapeutic strategy for autoimmune diseases

D Yadav, JY Lee, N Puranik, PS Chauhan, V Chavda… - Cells, 2022 - mdpi.com
Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease associated with the
central nervous system (CNS). Autoimmunity is caused by an abnormal immune response to …

Adoptive transfer of immunomodulatory M2 macrophages suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice via blockading NF-κB pathway

F Chu, M Shi, Y Lang, Z Chao, T Jin… - Clinical & …, 2021 - academic.oup.com
Macrophages play important roles in multiple sclerosis (MS) and experimental autoimmune
encephalomyelitis (EAE), and M2 macrophage may have anti-inflammatory effects. In this …

Targeted delivery platforms for the treatment of multiple sclerosis

Z Jan, S Mollazadeh, K Abnous… - Molecular …, 2022 - ACS Publications
Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system
(CNS) that presents with varying levels of disability in patients, displaying the significance of …

Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review

M Honsho, Y Fujiki - Membranes, 2023 - mdpi.com
Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether
bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the …

The role of MRI in the diagnosis of spinal cord tumors

JLR de Paiva, JV Sabino, FV Pereira, PA Okuda… - Seminars in Ultrasound …, 2023 - Elsevier
Spinal cord tumors are uncommon, and its multiple representatives not always have
pathognomonic characteristics, which poses a challenge for both patients and caring …

Ginsenoside-Re inhibits experimental autoimmune encephalomyelitis as a mouse model of multiple sclerosis by downregulating TLR4/MyD88/NF-κB signaling …

J Oh, TW Kwon, JH Choi, Y Kim, SK Moon, SY Nah… - Phytomedicine, 2024 - Elsevier
Background Ginsenosides are main active compounds of Panax ginseng with
pharmacological effects on immunological/neurological diseases. Recently, ginsenoside-Re …

[HTML][HTML] NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway

J Wang, X Song, G Tan, P Sun, L Guo, N Zhang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Objective: To investigate the effect of NAD+ on thymus autophagy in experimental
autoimmune encephalomyelitis (EAE) mice through SIRT1. Methods: Bioinformatic analysis …