Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …

Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …

Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …

Chronic viral infections often result in ineffective CD8 T-cell responses due to functional
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …

The virological and immunological features of hepatitis C virus (HCV) infection were studied
weekly for 6 months after accidental needlestick exposure in five health care workers, four of …

Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

Although hepatitis C virus (HCV) infection is very common, identification of patients during
acute infection is rare. Consequently, little is known about the immune response during this …

Approximately 4 million persons in the United States and probably more than 100 million
persons worldwide are infected with hepatitis C virus. The virus has the unique ability to …

Few hepatitis C virus (HCV) infections resolve spontaneously but those that do appear to
afford protective immunity. Second infections are usually shorter in duration and are less …