Co-stimulatory and co-inhibitory pathways in autoimmunity
Q Zhang, DAA Vignali - Immunity, 2016 - cell.com
The immune system is guided by a series of checks and balances, a major component of
which is a large array of co-stimulatory and co-inhibitory pathways that modulate the host …
which is a large array of co-stimulatory and co-inhibitory pathways that modulate the host …
ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases
DY Li, XZ Xiong - Frontiers in immunology, 2020 - frontiersin.org
Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also
widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) …
widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) …
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses
Artificial sweeteners are used as calorie-free sugar substitutes in many food products and
their consumption has increased substantially over the past years. Although generally …
their consumption has increased substantially over the past years. Although generally …
Regulation of adaptive immunity; the role of interleukin-10
Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its
recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and …
recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and …
Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses
Loss of p53 function contributes to the development of many cancers. While cell-
autonomous consequences of p53 mutation have been studied extensively, the role of p53 …
autonomous consequences of p53 mutation have been studied extensively, the role of p53 …
Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target
G Alvisi, A Termanini, C Soldani, F Portale… - Journal of …, 2022 - Elsevier
Background & Aims The landscape and function of the immune infiltrate of intrahepatic
cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly …
cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly …
Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator …
Background Atopic diseases, including asthma, exacerbate type 2 immune responses and
involve a number of immune cell types, including regulatory T (Treg) cells and the emerging …
involve a number of immune cell types, including regulatory T (Treg) cells and the emerging …
[HTML][HTML] ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy
JE Lopes, JL Fisher, HL Flick, C Wang… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Interleukin-2 (IL-2) plays a pivotal role in immune homeostasis due to its ability
to stimulate numerous lymphocyte subsets including natural killer (NK) cells, effector CD4+ …
to stimulate numerous lymphocyte subsets including natural killer (NK) cells, effector CD4+ …
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance
Adoptive transfer of Tregs has been shown to improve alloengraftment in animal models.
However, it is technically challenging to expand Tregs ex vivo for the purpose of infusing …
However, it is technically challenging to expand Tregs ex vivo for the purpose of infusing …
Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells
NAJ Dawson, I Rosado-Sánchez… - Science Translational …, 2020 - science.org
Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptors
(CARs) are a potent immunosuppressive cellular therapy in multiple disease models and …
(CARs) are a potent immunosuppressive cellular therapy in multiple disease models and …