Lung cancer (LCs) is still a serious health problem globally, with many incidences attributed
to environmental triggers such as Volatile Organic Compounds (VOCs). VOCs are a broad …

Introduction Mitochondrial transfer is a new cell-to-cell communication manner. Whether the
mitochondrial transfer is also involved in the macrophage infiltration-induced cardiac injury …

Subchronic and chronic reference values (RfVs) were derived for 1, 3-butadiene (BD) based
upon its ability to cause reproductive and developmental effects observed in laboratory mice …

Butadiene (BD) is a known human carcinogen used in the synthetic polymer industry and
also found in cigarette smoke, automobile exhaust and wood burning smoke. BD is …

Approximately 10% of smokers will develop lung cancer. Sensitive predictive biomarkers are
needed to identify susceptible individuals. 1, 3-Butadiene (BD) is among the most abundant …

1, 3-Butadiene is a known carcinogen primarily targeting lymphoid tissues, lung, and liver.
Cytochrome P450 activates butadiene to epoxides which form covalent DNA adducts that …

Diepoxybutane (DEB) is the most toxic metabolite of the environmental chemical 1, 3‐
butadiene. We previously demonstrated the occurrence of DEB‐induced p53‐mediated …

1, 3-Butadiene (BD) is a common environmental and industrial chemical widely used in
plastic and rubber manufacturing and also present in cigarette smoke and automobile …

Butadiene (BD) exposure is known to cause numerous adverse health effects, including
cancer, in animals and humans. BD is metabolized to reactive epoxide intermediates, which …

Reactions of the epoxides of 1, 3-butadiene and isoprene (2-methyl-1, 3-butadiene) with
oxygen, nitrogen and sulfur nucleophiles have been compared to enable a better molecular …