Sepsis‐induced brain dysfunction: pathogenesis, diagnosis, and treatment

S Pan, Z Lv, R Wang, H Shu, S Yuan… - … medicine and cellular …, 2022 - Wiley Online Library
Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …

[HTML][HTML] Central role of microglia in sepsis-associated encephalopathy: from mechanism to therapy

X Yan, K Yang, Q Xiao, R Hou, X Pan… - Frontiers in …, 2022 - frontiersin.org
Sepsis-associated encephalopathy (SAE) is a cognitive impairment associated with sepsis
that occurs in the absence of direct infection in the central nervous system or structural brain …

Sepsis-associated encephalopathy: from pathophysiology to clinical management

Y Hong, P Chen, J Gao, Y Lin, L Chen… - International …, 2023 - Elsevier
Sepsis-associated encephalopathy, which presents as delirium and coma, is a significant
complication of sepsis characterized by acute brain dysfunction. The presence of …

[HTML][HTML] β-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through Sirt1/Nrf2 …

Y Tian, L Wang, X Fan, H Zhang, Z Dong, T Tao - Plos one, 2023 - journals.plos.org
Background Sepsis associated encephalopathy (SAE) is a common but poorly understood
complication during sepsis. Currently, there are no preventive or therapeutic agents …

Acute and long-term cognitive impairment following sepsis: mechanism and prevention

MH Ji, YZ Gao, CN Shi, XM Wu… - Expert Review of …, 2023 - Taylor & Francis
Introduction Sepsis is a severe host response to infection, which induces both acute and
long-term cognitive impairment. Despite its high incidence following sepsis, the underlying …

BMP7 attenuates neuroinflammation after spinal cord Injury by suppressing the microglia activation and inducing microglial polarization Via the STAT3 pathway

X Wei, C Huang, K Chen, S Liu, M Wang, L Yang… - Neurochemical …, 2023 - Springer
Excessive activation of pro-inflammatory (M1) microglia phenotypes after spinal cord injury
(SCI) disrupts tissue repair and increases the risk of secondary SCI. We previously reported …

[HTML][HTML] Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis

N Mein, N von Stackelberg, J Wickel, C Geis… - Journal of …, 2023 - Springer
Background Sepsis-associated encephalopathy (SAE) is characterized by symptoms of
delirium including hallucinations, impaired concentration, agitation, or coma and is …

ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway

Y Li, TT Wan, JX Li, X Xiao, L Liu, HH Li… - Molecular Neurobiology, 2024 - Springer
Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated
encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a …

Regulation of oxygen–glucose deprivation/reperfusion-induced inflammatory responses and M1-M2 phenotype switch of BV2 microglia by lobetyolin

J Wang, X Liu, W Wei, J Yang, Q Li, S Chu, P Liu… - Metabolic Brain …, 2023 - Springer
To elucidate the protective mechanism of lobetyolin on oxygen–glucose deprivation/
reperfusion (OGD/R)-induced damage in BV2 microglial cells. The OGD/R model was …

Sepsis‐associated encephalopathy: Autophagy and miRNAs regulate microglial activation

N Qin, Y Miao, L Xie, X Ma, P Xie - Physiological Reports, 2024 - Wiley Online Library
Sepsis‐associated encephalopathy (SAE) describes diffuse or multifocal cerebral
dysfunction caused by the systemic inflammatory response to sepsis. SAE is a common …