This article presents a model‐based control approach for optimal operation of a seeded fed‐
batch evaporative crystallizer. Various direct optimization strategies, namely, single …

An in-line technique involving focused beam reflectance measurement (FBRM) for control of
crystal product quality in unseeded systems is proposed. The method consists of nucleation …

We describe the development of a triphasic quench-crystallization operation to isolate an
intermediate in the manufacture of the sotorasib drug substance. Using this case study …

The strategy for seeding and supersaturation control can play a critical role in defining the
purity and particle size distribution of crystal products. Previous research has demonstrated …

In this paper, a seed recipe design is proposed for batch cooling crystallization to obtain the
desired product attributes including product yield and product size distribution, based on …

Crystallization kinetics of ampicillin were estimated from induction-times and seeded and
unseeded experiments. The concentration of ampicillin in solution was monitored by …

A leading method for the crystallization of pharmaceutical compounds is to rapidly mix an
antisolvent with a solvent saturated with the desired drug. Compared to cross-flow mixers …

A model polymorphic co-crystallization process for caffeine-glutaric acid from acetonitrile
was monitored and controlled using attenuated total reflectance Fourier transform infrared …

Supersaturation is a factor of great industrial importance to the crystal growth by affecting the
final aspect ratio and morphology of organic compounds. In this work, the qualitative …

Secondary nucleation is suppressed in an air-lift crystallizer at levels of supersaturation
where in a stirred crystallizer a clear contribution of secondary nucleation is visible. A …