This work presents a systematic study for obtaining the optimal temperature profile in a
continuous plug flow crystallizer (PFC). The proposed PFC consists of multiple segments …

Many active pharmaceutical ingredients (APIs) undergo degradation at high temperature.
Optimum cooling profiles from first principle models usually do not consider this degradation …

This article describes a modification of the conventional membrane crystallization technique
in which a membrane is used to dose the solvent/antisolvent composition to generate …

A novel method for crystallization utilizing solvent/antisolvent extraction in microfluidic
droplet liquid reactors has been developed for rapid and low-cost screening of crystal …

The implementation and optimization of crystallization process control can be crucial to
achieve quality standards consistently in various industrial applications. To overcome …

Cooling crystallization of small organic molecules from solution is an important operation for
the separation and purification of drug products. In this research, shear-induced nucleation …

The optimization of unseeded batch cooling crystallization systems is studied in a
multiobjective framework. The length mean size and target aspect ratio (AR) of final crystals …

In this article, we demonstrate a model-based approach for controlling the average size of
crystals produced by batch cooling crystallization. The method is distinguished most notably …

The oiling out and crystallization behavior of a pharmaceutical compound from acetone and
water was studied using a range of in-situ tools to qualitatively describe the oiling out …

The aggregation of crystals within a flow tube was observed based on data extracted from
images of the bypassing population. The experiments were conducted under different …