CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

Chemokine receptors have a key role in the pathogenesis of autoimmune diseases,
inflammation and viral infection. However, with the exception of selective CCR5 antagonists …

Despite increasing knowledge about molecular pathways in pathogenesis of chronic liver
disease, selective therapeutic options are scarce, especially in advanced diseases …

Effector-T-cell-mediated immunity depends on the efficient localization of antigen-primed
lymphocytes to antigen-rich non-lymphoid tissue, which is facilitated by the expression of a …

purpose. Dry eye disease (DED) is associated with ocular surface inflammation that is
thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate …

This review presents evidence that dual targeting of CCR2 and CCR5 has greater
therapeutic potential than targeting either receptor alone. A cardinal feature of inflammation …

Chemokines are small basic proteins that are defined by the number and position of the
invariant cysteines in their protein sequence. 1 At the time this review was written more than …

Immune cells infiltrate the kidney, vasculature, and central nervous system during
hypertension, consequently amplifying tissue damage and/or blood pressure elevation …

Under homeostatic conditions, as well as in various diseases, leukocyte migration is a
crucial issue for the immune system that is mainly organized through the activation of bone …

Despite the critical role of cytokines in allograft rejection, the relation of peripheral blood
cytokine profiles to clinical kidney transplant rejection has not been fully elucidated. We …